{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:33:10Z","timestamp":1791246790964,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006244","name":"Stichting Kinderen Kankervrij","doi-asserted-by":"publisher","award":["KIKA project 84"],"award-info":[{"award-number":["KIKA project 84"]}],"id":[{"id":"10.13039\/501100006244","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Childhood cancer survivors (<jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content>) experience higher hospitalization rates compared to the general population for neoplasms, circulatory diseases, endocrine\/nutritional\/metabolic diseases and eye disorders. We studied trends in hospitalization rates and associated patient and treatment\u2010specific risk factors for diagnosis subgroups among these four diseases. We performed medical record linkage of a \u22655\u2010year <jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content> cohort with national registers, and obtained a random reference sample matched on age, gender and calendar year per <jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content>. For each diagnosis subgroup we compared hospitalization rates and trends over time in <jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content> and the reference population. Further, we analyzed risk factors for hospitalizations within the four <jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content> diagnosis groups. We used multivariate Poisson regression for all models. We retrieved hospitalization data from 1382 <jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content> and 26,583 reference persons. <jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content> had increased hospitalization rates for almost all diagnosis subgroups examined. Hospitalization rates for endocrine\/nutritional\/metabolic diseases appeared to increase with longer time since primary cancer diagnosis up to 30\u00a0years after primary cancer diagnosis. Survivors initially treated with radiotherapy had increased hospitalization rates for neoplasms (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), those initially treated with anthracyclines (2.5 [1.1\u20135.5]) and radiotherapy to thorax and\/or abdomen (9.3 [2.4\u201336.6]) had increased hospitalization rates for diseases of the circulatory system, and those initially treated with radiotherapy to head and\/or neck had increased hospitalization rates for endocrine\/nutritional\/metabolic diseases (6.7 [3.5\u201312.7]) and diseases of the eye (3.6 [1.5\u20138.9]). Our study highlights that long\u2010term health problems resulting in hospitalizations are still clinically relevant later in life of <jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content>. The identified treatment\u2010related risk factors associated with hospitalizations support targeted follow\u2010up care for these risk groups of <jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/cam4.1057","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T17:30:59Z","timestamp":1491413459000},"page":"1123-1134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Risk and associated risk factors of hospitalization for specific health problems over time in childhood cancer survivors: a medical record linkage study"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2292-3204","authenticated-orcid":false,"given":"Anna","family":"Font\u2010Gonzalez","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology Emma Children's Hospital\/Academic Medical Centre  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth (Lieke) A.M.","family":"Feijen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Emma Children's Hospital\/Academic Medical Centre  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald B.","family":"Geskus","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Biostatistics and Bioinformatics Academic Medical Centre  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel G.W.","family":"Dijkgraaf","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena J.H.","family":"van der Pal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Emma Children's Hospital\/Academic Medical Centre  Amsterdam The Netherlands"},{"name":"Department of Medical Oncology Academic Medical Centre  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Heinen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Emma Children's Hospital\/Academic Medical Centre  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique W.","family":"Jaspers","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics Center for Human Factors Engineering of Health Information Technology (HITlab) Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora E.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology National Cancer Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.B. 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