{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:25:57Z","timestamp":1780532757075,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004397","name":"Ministry of Public Health","doi-asserted-by":"publisher","award":["201402010"],"award-info":[{"award-number":["201402010"]}],"id":[{"id":"10.13039\/501100004397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytology\u2010based cervical cancer screening is restricted because of a lack of cytologists. Thus, <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010based instead of cytology\u2010based screening may be a more suitable strategy in China. Here, we assessed the effectiveness of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> testing (Cobas<jats:sup>\u00ae<\/jats:sup> 4800 Test, Roche) and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010based programs to detect high\u2010grade cervical intraepithelial neoplasia (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>) or cancer compared with cytology (Thinprep, Hologic) and cytology\u2010based programs through a cross\u2010sectional study in 11,064 Chinese women aged 21\u201365\u00a0years who were enrolled from Longyou County in Zhejiang Province, China. The rates of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> positivity and cytology abnormality were 9.8% and 6.1%, respectively. The <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> positivity rate had two age peaks, 21\u201324 (15.4%) and 60\u201365 (14.4%) years. According to adjusted data, <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> testing demonstrated significantly higher sensitivity and negative predictive value (<jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content>) than cytology for detecting <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2 or worse (90.0% vs. 66.7%, 99.9% vs. 99.5%), and there was an acceptable specificity (91.3%) and positive predictive value (<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>, 12.5%). Furthermore, primary <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> testing with type 16\/18 genotyping showed the highest sensitivity (78.6%) and <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> (99.7%) among four screening strategies, and there was similar specificity (96.8%) and <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> (23.9%) compared with co\u2010testing screening to detect <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+, while there were fewer colposcopies (4.2) and tests (106.3) performed than with co\u2010testing and primary cytology screening to detect a case of high\u2010grade <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>. The differences in effectiveness were approximately similar when <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3+ was the identifying target. Our findings suggest that primary <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> testing with type 16\/18 genotyping has a higher sensitivity and <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content>, possesses optimal cost\/effectiveness in the first round of screening and is a feasible strategy of cervical cancer screening for Chinese women.<\/jats:p>","DOI":"10.1002\/cam4.1060","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T17:36:27Z","timestamp":1491413787000},"page":"1091-1101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A cross\u2010sectional study on HPV testing with type 16\/18 genotyping for cervical cancer screening in 11,064 Chinese women"],"prefix":"10.1002","volume":"6","author":[{"given":"Qiongyan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology Women's Hospital School of Medicine Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Women's Reproductive Health of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Women's Hospital School of Medicine Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Women's Reproductive Health of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Women's Hospital School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Women's Hospital School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Women's Hospital School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Tian","sequence":"additional","affiliation":[{"name":"Cancer Biology Research Center (Key laboratory of the ministry of education) Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Women's Hospital School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingjian","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pathology Women's Hospital School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gynecology Women &amp; Children Healthcare Hospital of Quzhou City  Quzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suqiu","family":"Lan","sequence":"additional","affiliation":[{"name":"Longyou County Maternal and Child Health\u2010Care Center  Quzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Women's Hospital School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Ma","sequence":"additional","affiliation":[{"name":"Cancer Biology Research Center (Key laboratory of the ministry of education) Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Women's Hospital School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1636-4816","authenticated-orcid":false,"given":"Xing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Women's Hospital School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"2120","article-title":"Consensus Guidelines for the management of women with cervical cytological abnormalities","volume":"2002","author":"Wright T. 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