{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:40:03Z","timestamp":1740166803654,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T00:00:00Z","timestamp":1495497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aim of this study is to explore the role of different treatments on the development of secondary malignancies (<jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content>s) in a large cohort of essential thrombocythemia (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>) patients. We report the experience of a regional cooperative group in a real\u2010life cohort of 1026 patients with <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>. We divided our population into five different groups: group 0, no treatment; group 1, hydroxyurea (<jats:styled-content style=\"fixed-case\">HU<\/jats:styled-content>); group 2, alkylating agents (<jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content>); group 3, <jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">HU<\/jats:styled-content> sequentially or in combination; and group 4, anagrelide (<jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content>) and\/or <jats:italic>\u03b1<\/jats:italic>\u2010interferon (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>) only. Patients from groups 1, 2, and 3 could also have been treated either with <jats:styled-content style=\"fixed-case\">ANA<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> in their medical history, considering these drugs not to have an additional cytotoxic potential. In all, 63 of the 1026 patients (6%) developed 64 <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content> during the follow\u2010up, after a median time of 50\u00a0months (range: 2\u2013158) from diagnosis. In univariate analysis, a statistically significant difference was found only for gender (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.035) and age (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001). In multivariate analysis, a statistically significant difference was maintained for both gender and age (gender <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>1.7 [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 95% 1.037\u20132.818] <jats:italic>P<\/jats:italic>\u00a0=\u00a00.035; age <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 4.190 [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 95% 2.308\u20137.607] <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001). The impact of different treatments on <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content>s development was not statistically significant. In our series of 1026 <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> patients, diagnosed and followed during a 30\u2010year period, the different therapies administered, comprising <jats:styled-content style=\"fixed-case\">HU<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content>, do not appear to have impacted on the development of <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content>. A similar rate of <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content>s was observed also in untreated patients. The only two variables which showed a statistical significance were male gender and age &gt;60\u00a0years.<\/jats:p>","DOI":"10.1002\/cam4.1081","type":"journal-article","created":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:50:33Z","timestamp":1495587033000},"page":"1233-1239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Role of treatment on the development of secondary malignancies in patients with essential thrombocythemia"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7181-447X","authenticated-orcid":false,"given":"Cristina","family":"Santoro","sequence":"first","affiliation":[{"name":"Hematology, Department of Cellular Biotechnologies and Hematology Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Sperduti","sequence":"additional","affiliation":[{"name":"Biostatistical Unit Regina Elena National Cancer Institute  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7741-862X","authenticated-orcid":false,"given":"Roberto","family":"Latagliata","sequence":"additional","affiliation":[{"name":"Hematology, Department of Cellular Biotechnologies and Hematology Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erminia","family":"Baldacci","sequence":"additional","affiliation":[{"name":"Hematology, Department of Cellular Biotechnologies and Hematology Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Anaclerico","sequence":"additional","affiliation":[{"name":"Hematology San Giovanni Hospital  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Avvisati","sequence":"additional","affiliation":[{"name":"Hematology University Campus Biomedico  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Breccia","sequence":"additional","affiliation":[{"name":"Hematology, Department of Cellular Biotechnologies and Hematology Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Buccisano","sequence":"additional","affiliation":[{"name":"Hematology University Tor Vergata  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Cedrone","sequence":"additional","affiliation":[{"name":"Hematology San Giovanni Hospital  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Cimino","sequence":"additional","affiliation":[{"name":"Hematology Polo Universitario Pontino  Latina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"De Gregoris","sequence":"additional","affiliation":[{"name":"Hematology Belcolle Hospital  Viterbo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"De Muro","sequence":"additional","affiliation":[{"name":"Hematology University Campus Biomedico  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2876-4833","authenticated-orcid":false,"given":"Ambra","family":"Di Veroli","sequence":"additional","affiliation":[{"name":"Hematology University Tor Vergata  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Leonetti\u00a0Crescenzi","sequence":"additional","affiliation":[{"name":"Hematology Sandro Pertini Hospital  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Montanaro","sequence":"additional","affiliation":[{"name":"Hematology Belcolle Hospital  Viterbo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Montefusco","sequence":"additional","affiliation":[{"name":"Hematology Sant'Andrea Hospital  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Porrini","sequence":"additional","affiliation":[{"name":"Hematology Sant'Andrea Hospital  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Rago","sequence":"additional","affiliation":[{"name":"Hematology Polo Universitario Pontino  Latina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Spadea","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplant Unit Regina Elena National Cancer Unit  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Spirito","sequence":"additional","affiliation":[{"name":"Hematology San Camillo Hospital  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Villiv\u00e0","sequence":"additional","affiliation":[{"name":"Hematology Nuovo Regina Margherita Hospital ASL Roma 1  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alesssandro","family":"Andriani","sequence":"additional","affiliation":[{"name":"Hematology Nuovo Regina Margherita Hospital ASL Roma 1  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliana","family":"Alimena","sequence":"additional","affiliation":[{"name":"Hematology, Department of Cellular Biotechnologies and Hematology Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Gabriella","family":"Mazzucconi","sequence":"additional","affiliation":[{"name":"Hematology, Department of Cellular Biotechnologies and Hematology Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,23]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1002\/1097-0142(19900801)66:3<549::AID-CNCR2820660324>3.0.CO;2-6"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1200\/JCO.1990.8.3.556"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.3324\/haematol.13346"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1016\/j.amjmed.2004.06.032"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1054\/blre.2001.0158"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1046\/j.1365-2141.2002.03474.x"},{"key":"e_1_2_6_8_1","first-page":"215","article-title":"Practice guidelines for the therapy of essential thrombocythemia. A statement from the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation","volume":"89","author":"Barbui T.","year":"2004","journal-title":"Haematologica"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.1111\/j.1365-2141.2010.08122.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.1056\/NEJM199504273321704"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1016\/0165-4608(90)90164-6"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1159\/000204260"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1111\/j.1600-0609.1994.tb01303.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.1002\/(SICI)1096-8652(199605)52:1<42::AID-AJH7>3.0.CO;2-6"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1182\/blood.V91.2.616","article-title":"Acute myeloid leukemia and myelodysplastic syndromes following essential thrombocythemia treated withhydroxyurea: high proportion of cases with 17p deletion","volume":"91","author":"Sterkers Y.","year":"1998","journal-title":"Blood"},{"key":"e_1_2_6_16_1","first-page":"29","article-title":"Experience of the Polycythemia Vera Study Group with essential thrombocythemia: a final report on diagnostic criteria, survival, and leukemic transition by treatment","volume":"34","author":"Murphy S.","year":"1997","journal-title":"Semin Hematol"},{"doi-asserted-by":"publisher","key":"e_1_2_6_17_1","DOI":"10.3109\/10428190009089438"},{"doi-asserted-by":"publisher","key":"e_1_2_6_18_1","DOI":"10.1046\/j.1365-2141.2003.04542.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_19_1","DOI":"10.1179\/102453308X316022"},{"doi-asserted-by":"publisher","key":"e_1_2_6_20_1","DOI":"10.1111\/ejh.12437"},{"doi-asserted-by":"publisher","key":"e_1_2_6_21_1","DOI":"10.1016\/j.leukres.2014.07.006"},{"issue":"1","key":"e_1_2_6_22_1","first-page":"9","article-title":"Diagnostic criteria and prognosis in polycythemia vera and essential thrombocythemia","volume":"36","author":"Murphy S.","year":"1999","journal-title":"Semin Hematol"},{"doi-asserted-by":"publisher","key":"e_1_2_6_23_1","DOI":"10.1182\/blood-2009-03-209262"},{"key":"e_1_2_6_24_1","first-page":"48","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Thiele J.","year":"2008"},{"doi-asserted-by":"publisher","key":"e_1_2_6_25_1","DOI":"10.1182\/blood-2011-04-348755"},{"doi-asserted-by":"publisher","key":"e_1_2_6_26_1","DOI":"10.1182\/blood-2011-12-401455"},{"doi-asserted-by":"publisher","key":"e_1_2_6_27_1","DOI":"10.1046\/j.1365-2141.2000.02188.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_28_1","DOI":"10.3109\/10428194.2015.1041392"},{"doi-asserted-by":"publisher","key":"e_1_2_6_29_1","DOI":"10.3324\/haematol.2009.020412"},{"doi-asserted-by":"publisher","key":"e_1_2_6_30_1","DOI":"10.1182\/blood-2011-11-394775"},{"doi-asserted-by":"publisher","key":"e_1_2_6_31_1","DOI":"10.1016\/j.leukres.2012.10.020"},{"doi-asserted-by":"publisher","key":"e_1_2_6_32_1","DOI":"10.1016\/S0140-6736(00)04046-0"},{"doi-asserted-by":"publisher","key":"e_1_2_6_33_1","DOI":"10.3109\/07853890903405753"},{"doi-asserted-by":"publisher","key":"e_1_2_6_34_1","DOI":"10.1016\/j.cytogfr.2013.01.004"},{"doi-asserted-by":"publisher","key":"e_1_2_6_35_1","DOI":"10.1158\/1055-9965.EPI-09-0353"},{"doi-asserted-by":"publisher","key":"e_1_2_6_36_1","DOI":"10.1093\/aje\/kwq262"},{"doi-asserted-by":"publisher","key":"e_1_2_6_37_1","DOI":"10.1111\/j.1365-2141.2010.08538.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_38_1","DOI":"10.1517\/14656566.2013.799140"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.1081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.1081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T18:21:05Z","timestamp":1696616465000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.1081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,23]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1002\/cam4.1081"],"URL":"https:\/\/doi.org\/10.1002\/cam4.1081","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"type":"print","value":"2045-7634"},{"type":"electronic","value":"2045-7634"}],"subject":[],"published":{"date-parts":[[2017,5,23]]},"assertion":[{"value":"2016-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}