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Despite many improvements in multiple strategies of chemotherapy, immunotherapy, and targeted therapy, exploration of novel alternative therapeutic targets is still warranted. Chemokine receptor 4 (\n                    <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>\n                    4) and its chemokine ligand 12 (\n                    <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\n                    12) have been identified with significantly elevated levels in various malignancies including\n                    <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\n                    , which correlates with the survival, proliferation, angiogenesis, and metastasis of tumor cells. Increasing experimental evidence suggests an implication of inhibition of\n                    <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\n                    12\/\n                    <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>\n                    4 axis as a promising targeted therapy, although there are rare trials focused on the therapeutic efficacy of\n                    <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>\n                    4 inhibitors in\n                    <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\n                    until recently. Therefore, it is reasonable to infer that specific antagonists or antibodies targeting\n                    <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\n                    12\/\n                    <jats:styled-content style=\"fixed-case\">CXCR<\/jats:styled-content>\n                    4 axis alone or combined with chemotherapy will be effective and worthy of further translational studies as a potential treatment strategy in advanced\n                    <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/cam4.1085","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T20:50:59Z","timestamp":1495572659000},"page":"1424-1436","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Inhibition of CXCL12\/CXCR4 axis as a potential targeted therapy of advanced gastric carcinoma"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4510-528X","authenticated-orcid":false,"given":"Li\u2010Jun","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Jinling Hospital Nanjing University Clinical School of Medicine  Nanjing 210002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Bei","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jinling Hospital Nanjing University Clinical School of Medicine  Nanjing 210002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Li","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jinling Hospital Nanjing University Clinical School of Medicine  Nanjing 210002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Yuan","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jinling Hospital Nanjing University Clinical School of Medicine  Nanjing 210002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.5688"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.941"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61121-X"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61719-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70420-6"},{"key":"e_1_2_10_7_1","first-page":"4011","article-title":"A randomized, open\u2010label, two\u2010arm phase II trial comparing the efficacy of sequential ipilimumab (ipi) versus best supportive care (BSC) following first\u2010line (1L) chemotherapy in patients with unresectable, locally advanced\/metastatic (A\/M) gastric or gastro\u2010esophageal junction (G\/GEJ) cancer","volume":"34","author":"Moehler M. 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