{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:34:27Z","timestamp":1790361267131,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,4]],"date-time":"2017-06-04T00:00:00Z","timestamp":1496534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006388","name":"H\u00f4pitaux Universitaires de Gen\u00e8ve","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006388","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Abstract<\/jats:title>Cervical cancer (CC<\/jats:styled-content>) is the leading cause of cancer\u2010related death among women in sub\u2010Saharan Africa, primarily because of limited access to effective screening and preventive treatment. Our aim was to assess the feasibility of a human papillomavirus (HPV<\/jats:styled-content>)\u2010based CC<\/jats:styled-content> screen\u2010and\u2010treat approach in a low\u2010resource context. We recruited 1012 women aged 30\u201349\u00a0years through a CC<\/jats:styled-content> screening campaign conducted in the District Hospital of Dschang, Cameroon. Participants performed HPV<\/jats:styled-content> self\u2010sampling, which was tested for high\u2010risk HPV<\/jats:styled-content> (HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content>) DNA<\/jats:styled-content> using the point\u2010of\u2010care Xpert HPV<\/jats:styled-content> assay. All HPV<\/jats:styled-content>\u2010positive women were invited for visual inspection with acetic acid and Lugol's iodine (VIA<\/jats:styled-content>\/VILI<\/jats:styled-content>) to exclude CC<\/jats:styled-content> or enable triage. A cervical sample for histological analysis was also collected. Women positive for HPV<\/jats:styled-content> 16\/18\/45 and for other HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content> with pathological VIA<\/jats:styled-content>\/VILI<\/jats:styled-content> were selected to undergo treatment with thermocoagulation. The HPV<\/jats:styled-content> prevalence in the study population was 18.5% (n<\/jats:italic>\u00a0=\u00a0187); of these cases, 20 (10.6%), 42 (22.3%) and 140 (74.9%) were positive for HPV<\/jats:styled-content>16, HPV<\/jats:styled-content>18\/45 and other HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content> types, respectively. Overall, 107\/185 (57.8%) VIA<\/jats:styled-content>\/VILI<\/jats:styled-content> examinations were classified as pathological and 78 (42.2%) as normal. Women positive for HPV<\/jats:styled-content>16\/18\/45 were 4.2 times more likely to harbor cervical intraepithelial neoplasia grade 2 or worse (CIN<\/jats:styled-content>2+) than those with other HPV<\/jats:styled-content> types. The specificity of HPV<\/jats:styled-content> 16\/18\/45 genotypes for detection of high\u2010grade lesions among HR<\/jats:styled-content>\u2010HPV<\/jats:styled-content> positive women was higher than that of VIA<\/jats:styled-content>\/VILI<\/jats:styled-content> in all age groups. The sensitivity and specificity of VIA<\/jats:styled-content>\/VILI<\/jats:styled-content> in detecting CIN<\/jats:styled-content>2+ among HPV<\/jats:styled-content> positive women were 80% and 44%, respectively. Overall, 110\/121 screen\u2010positive women (90.9%) were eligible for, and were treated with, thermocoagulation. An HPV<\/jats:styled-content>\u2010based screen\u2010and\u2010treat approach is feasible in a low\u2010resource context and may contribute to improving the effectiveness of CC<\/jats:styled-content> prevention programs. Immediate thermocoagulation treatment for women who are HPV<\/jats:styled-content>16\u2010 and\/or HPV<\/jats:styled-content>18\/45\u2010positive is a practical approach for the treatment of CIN<\/jats:styled-content>2+. The combination of HPV<\/jats:styled-content>\u2010testing and VIA<\/jats:styled-content>\/VILI<\/jats:styled-content> for CC<\/jats:styled-content> screening might reduce overtreatment.<\/jats:p>","DOI":"10.1002\/cam4.1089","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T04:24:43Z","timestamp":1496636683000},"page":"1752-1761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Cervical cancer screening in a low\u2010resource setting: a pilot study on an HPV\u2010based screen\u2010and\u2010treat approach"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5431-8418","authenticated-orcid":false,"given":"Margot","family":"Kunckler","sequence":"first","affiliation":[{"name":"Gynecology Division Department of Obstetrics and Gynecology University Hospitals of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Gynecology Division Department of Obstetrics and Gynecology University Hospitals of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Kenfack","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Dschang Dschang District Hospital Dschang Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Catarino","sequence":"additional","affiliation":[{"name":"Gynecology Division Department of Obstetrics and Gynecology University Hospitals of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Viviano","sequence":"additional","affiliation":[{"name":"Gynecology Division Department of Obstetrics and Gynecology University Hospitals of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline","family":"Tincho","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences Centre Hospitalier Universitaire (CHUY) Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Marie","family":"Tebeu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences Centre Hospitalier Universitaire (CHUY) Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane","family":"Temogne","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences Centre Hospitalier Universitaire (CHUY) Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Vassilakos","sequence":"additional","affiliation":[{"name":"Geneva Foundation for Medical Education and Research Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Petignat","sequence":"additional","affiliation":[{"name":"Gynecology Division Department of Obstetrics and Gynecology University Hospitals of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr015"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2016.03.011"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071430"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62218-7"},{"key":"e_1_2_6_6_1","first-page":"594","article-title":"Effective screening programs for cervical cancer in low\u2010 and middle\u2010 income developing countries","volume":"79","author":"Sankaranarayanan R.","year":"2001","journal-title":"Bull. 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