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We have investigated this relationship in a cohort of pancreatic cancer patients from Western Norway (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>237) and two control materials (healthy blood donors, <jats:italic>n<\/jats:italic>\u00a0=\u00a0379; unselected hospitalized patients, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>6149). When comparing patient and blood donor <jats:italic><jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content><\/jats:italic> allele frequencies, we found only the A<jats:sub>1<\/jats:sub> allele to be associated with significantly higher risk for pancreatic ductal adenocarcinoma (<jats:styled-content style=\"fixed-case\">PDAC<\/jats:styled-content>) (23.8% vs. 17.9%; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.43, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.018). Analyzing phenotypes, blood group A was more frequent among <jats:styled-content style=\"fixed-case\">PDAC<\/jats:styled-content> cases than blood donors (50.8% vs. 40.6%; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.51, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.021), an enrichment fully explained by the A<jats:sub>1<\/jats:sub> subgroup. Blood group O frequency was lower in cases than in blood donors (33.8% vs. 42.7%; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.69, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.039). This lower frequency was confirmed when cases were compared to hospitalized patients (33.8% vs. 42.9%; OR\u00a0=\u00a00.68, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.012). Results for blood group B varied according to which control cohort was used for comparison. When patients were classified according to surgical treatment, the enrichment of blood group A was most prominent among unresected cases (54.0%), who also had the lowest prevalence of O (28.7%). There was a statistically significant better survival (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04) for blood group O cases than non\u2010O cases among unresected but not among resected patients. Secretor status did not show an association with <jats:styled-content style=\"fixed-case\">PDAC<\/jats:styled-content> or survival. Our study demonstrates that pancreatic cancer risk is influenced by <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> status, in particular blood groups O and A<jats:sub>1<\/jats:sub>, and that this association may reflect also in tumor resectability and survival.<\/jats:p>","DOI":"10.1002\/cam4.1097","type":"journal-article","created":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T09:02:45Z","timestamp":1496048565000},"page":"1531-1540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Associations between <scp>ABO<\/scp> blood groups and pancreatic ductal adenocarcinoma: influence on resection status and survival"],"prefix":"10.1002","volume":"6","author":[{"given":"Khadija","family":"El Jellas","sequence":"first","affiliation":[{"name":"Gade Laboratory for Pathology Department of Clinical Medicine University of Bergen  Bergen Norway"},{"name":"Department of Pathology Haukeland University Hospital  Bergen Norway"},{"name":"Center for Medical Genetics and Molecular Medicine Haukeland University Hospital  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Hoem","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Haukeland University Hospital  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin G","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Haukeland University Hospital  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May Britt","family":"Kalvenes","sequence":"additional","affiliation":[{"name":"Gade Laboratory for Pathology Department of Clinical Medicine University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sura","family":"Aziz","sequence":"additional","affiliation":[{"name":"Gade Laboratory for Pathology 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