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We examined the association between <jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content> and survival among cancer patients treated with bone\u2010targeted agents. Using nationwide registries and databases in Denmark, we identified 184 cancer patients with incident <jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content> between 2010 and 2015, and a comparison cohort of 1067 cancer patients without <jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content> and with a history of hospital\u2010administered treatment with bisphosphonates or denosumab initiating from cancer diagnosis. At the date of confirmed <jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content> diagnosis, the comparison cohort was matched to the <jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content> patients on age, cancer site, year of cancer diagnosis, and stage at diagnosis. The patients were followed up for survival until emigration or 15 June 2016. We computed overall survival and estimated mortality rate ratios adjusted for sex, and for the presence of distant metastases and other comorbidity at start of follow\u2010up. A match was found for 149 of the 184 <jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content> patients. The 1\u2010 and 3\u2010year survival among all 184 cancer patients with <jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content> was 70% (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]: 63%\u201376%) and 42% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 34%\u201351%), respectively. Among the matched patients, <jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content> was associated with an adjusted mortality rate ratio of 1.31 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.01\u20131.71). <jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content> was associated with reduced survival among cancer patients treated with bone\u2010targeted agents. <jats:styled-content style=\"fixed-case\">ONJ<\/jats:styled-content> may be a marker of advanced disease or of survival\u2010related lifestyle characteristics.<\/jats:p>","DOI":"10.1002\/cam4.1173","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T04:08:47Z","timestamp":1506053327000},"page":"2271-2277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Osteonecrosis of the jaw and survival of patients with cancer: a nationwide cohort study in Denmark"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7494-8932","authenticated-orcid":false,"given":"Priscila","family":"Corraini","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uffe","family":"Heide\u2010J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Schi\u00f8dt","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Rigshospitalet  Copenhagen \u00d8 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven Erik","family":"N\u00f8rholt","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Aarhus University and Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Acquavella","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Toft","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Ehrenstein","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu103"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu519"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs263"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2017.02.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60908-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3211"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-013-0561-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-2022-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60995-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12861"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr435"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70302-X"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2013.03.019"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-0882-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn630"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.1877"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810393562"},{"key":"e_1_2_7_23_1","first-page":"535","article-title":"The Danish Cancer Registry \u2010 history, content, quality and use","volume":"44","author":"Storm H. 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