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HCC<\/jats:styled-content> patients who underwent resection were divided into three groups: HBV<\/jats:styled-content>(+)\/AFB<\/jats:styled-content>1(+) (n<\/jats:italic>\u00a0=\u00a026), HBV<\/jats:styled-content>(+)\/AFB<\/jats:styled-content>1(\u2212) (n<\/jats:italic>\u00a0=\u00a068), and HBV<\/jats:styled-content>(\u2212)\/AFB<\/jats:styled-content>1(\u2212) (n<\/jats:italic>\u00a0=\u00a014). The groups were compared in terms of mRNA<\/jats:styled-content> and protein levels of P62, disease\u2010free survival (DFS<\/jats:styled-content>), and overall survival (OS<\/jats:styled-content>) and the expression of NRF<\/jats:styled-content>2, Nqo1, and AKR<\/jats:styled-content>7A3 in P62 high\u2010expression and low\u2010expression group. HBV<\/jats:styled-content>(+)\/AFB<\/jats:styled-content>1(+) group has lower DFS<\/jats:styled-content> and OS<\/jats:styled-content>, and higher P62 expression than in the other two groups. P62 expression generally correlated with elevated NRF<\/jats:styled-content>2 and Nqo1 expression, and reduced AKR<\/jats:styled-content>7A3 expression. Patients expressing high levels of P62 showed significantly lower DFS<\/jats:styled-content> and OS<\/jats:styled-content> rates than patients expressing low levels. HCC<\/jats:styled-content> involving HBV<\/jats:styled-content> infection and AFB<\/jats:styled-content>1 exposure is associated with relatively high risk of tumor recurrence, and this poor prognosis may relate to high P62 expression. High P62 expression activates the NRF<\/jats:styled-content>2 pathway, promotes tumor recurrence. The downregulation of AKR<\/jats:styled-content>7A3 also reduced liver detoxification of aflatoxin B1.<\/jats:p>","DOI":"10.1002\/cam4.1176","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T10:46:53Z","timestamp":1505990813000},"page":"2357-2369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Expression of P62 in hepatocellular carcinoma involving hepatitis B virus infection and aflatoxin B1 exposure"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7143-0196","authenticated-orcid":false,"given":"Xiao","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Guangxi Cancer Institute Hospital Oncology School Guangxi Cancer Center Nanning 530021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Gui","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Guangxi Cancer Institute Hospital Oncology School Guangxi Cancer Center Nanning 530021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Mei","family":"You","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Guangxi Cancer Institute Hospital Oncology School Guangxi Cancer Center Nanning 530021 China"},{"name":"Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center Nanning 530021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Guangxi Cancer Institute Hospital Oncology School Guangxi Cancer Center Nanning 530021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u2010Nan","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Guangxi Cancer Institute Hospital Oncology School Guangxi Cancer Center Nanning 530021 China"},{"name":"Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center Nanning 530021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Guangxi Cancer Institute Hospital Oncology School Guangxi Cancer Center Nanning 530021 China"},{"name":"Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center Nanning 530021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bang\u2010De","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Guangxi Cancer Institute Hospital Oncology School Guangxi Cancer Center Nanning 530021 China"},{"name":"Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center Nanning 530021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1494-6396","authenticated-orcid":false,"given":"Jian\u2010Hong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Guangxi Cancer Institute Hospital Oncology School Guangxi Cancer Center Nanning 530021 China"},{"name":"Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center Nanning 530021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le\u2010Qun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Tumor Hospital of Guangxi Medical University Guangxi Cancer Institute Hospital Oncology School Guangxi Cancer Center Nanning 530021 China"},{"name":"Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center Nanning 530021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.12.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.3.743"},{"key":"e_1_2_7_6_1","first-page":"352","article-title":"Epidemiology, risk factors and surveillance of hepatocellular carcinoma","volume":"14","author":"Cabibbo G.","year":"2010","journal-title":"Eur. 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