{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:33:27Z","timestamp":1762079607250,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:00:00Z","timestamp":1505952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to evaluate the role of metabolic parameters analyzed at baseline and at interim FDG\u2010PET in predicting disease outcome in unresectable MPM patients receiving pemetrexed\u2010based chemotherapy. A consecutive series of MPM patients treated between February 2004 and July 2013 with first\u2010line pemetrexed\u2010based chemotherapy, and evaluated by FDG\u2010PET and CT scan at baseline and after two cycles of chemotherapy, was reviewed. Best CT scan response was assessed according to modified RECIST criteria. Progression\u2010free survival (PFS) and overall survival (OS) were correlated with FDG\u2010PET parameters, such as maximum standardized uptake value (SUV<jats:sub>max<\/jats:sub>), total lesion glycolysis (TLG), and percentage changes in SUV<jats:sub>max<\/jats:sub> (\u2206SUV) and TLG (\u2206TLG). Overall, 142 patients were enrolled; 77 (54%) received talc pleurodesis before chemotherapy. Baseline SUV<jats:sub>max<\/jats:sub> and TLG showed a statistically significant correlation with PFS and OS (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) in both group of patients (treated and untreated with pleurodesis). In 65 patients not receiving pleurodesis, SUV<jats:sub>max<\/jats:sub> reduction \u226525% (\u2206SUV\u00a0\u2265\u00a025%) and TLG reduction \u226530% (\u2206TLG\u00a0\u2265\u00a030%) were significantly associated with longer PFS (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Patients showing both \u2206SUV\u00a0\u2265\u00a025% and \u2206TLG\u00a0\u2265\u00a030% responses had a significant reduction in the risk of disease progression (HR:0.31, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and death (HR:0.52, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.044). Neither \u2206SUV nor \u2206TLG showed similar association with survival outcomes in patients treated with pleurodesis. Our study confirmed the prognostic role of baseline FDG\u2010PET in a large series of MPM patients treated with first\u2010line pemetrexed\u2010based chemotherapy. Moreover, use of \u2206SUV\u00a0\u2265\u00a025% and \u2206TLG\u00a0\u2265\u00a030% as cut\u2010off values to define early metabolic response supported the role of FDG\u2010PET in predicting disease outcome and treatment response in patients not receiving pleurodesis.<\/jats:p>","DOI":"10.1002\/cam4.1182","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T10:50:03Z","timestamp":1505991003000},"page":"2287-2296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prognostic and predictive role of [<sup>18<\/sup>F]fluorodeoxyglucose positron emission tomography (FDG\u2010PET) in patients with unresectable malignant pleural mesothelioma (MPM) treated with up\u2010front pemetrexed\u2010based chemotherapy"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2274-1702","authenticated-orcid":false,"given":"Paolo Andrea","family":"Zucali","sequence":"first","affiliation":[{"name":"Oncology Humanitas Clinical and Research Hospital  Rozzano (Milan) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egesta","family":"Lopci","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Humanitas Clinical and Research Hospital  Rozzano (Milan) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Luca","family":"Ceresoli","sequence":"additional","affiliation":[{"name":"Oncology Humanitas Gavazzeni Clinic  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Giordano","sequence":"additional","affiliation":[{"name":"Biostatistics Humanitas Clinical and Research Hospital  Rozzano (Milan) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Perrino","sequence":"additional","affiliation":[{"name":"Oncology Humanitas Clinical and Research Hospital  Rozzano (Milan) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Ciocia","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Humanitas Gavazzeni Clinic  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia","family":"Gianoncelli","sequence":"additional","affiliation":[{"name":"Oncology Humanitas Clinical and Research Hospital  Rozzano (Milan) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Lorenzi","sequence":"additional","affiliation":[{"name":"Oncology Humanitas Clinical and Research Hospital  Rozzano (Milan) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Simonelli","sequence":"additional","affiliation":[{"name":"Oncology Humanitas Clinical and Research Hospital  Rozzano (Milan) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"De Vincenzo","sequence":"additional","affiliation":[{"name":"Oncology Humanitas Clinical and Research Hospital  Rozzano (Milan) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia Rebecca","family":"Setti","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Humanitas Gavazzeni Clinic  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiana","family":"Bonifacio","sequence":"additional","affiliation":[{"name":"Radiology Humanitas Clinical and Research Hospital  Rozzano (Milan) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Bonomi","sequence":"additional","affiliation":[{"name":"Oncology Humanitas Gavazzeni Clinic  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Bombardieri","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Humanitas Gavazzeni Clinic  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Chiti","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Humanitas Clinical and Research Hospital  Rozzano (Milan) Italy"},{"name":"Humanitas University  Rozzano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Santoro","sequence":"additional","affiliation":[{"name":"Oncology Humanitas Clinical and Research Hospital  Rozzano (Milan) Italy"},{"name":"Humanitas University  Rozzano Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,21]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"491","article-title":"Malignant pleural mesothelioma: an epidemiological perspective","volume":"1","author":"Robinson B. 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