{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:57:22Z","timestamp":1790416642541,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:00:00Z","timestamp":1505952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JSPS KAKENHI"],"award-info":[{"award-number":["JSPS KAKENHI"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP16K08752"],"award-info":[{"award-number":["JP16K08752"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although oncolytic adenoviruses are promising cancer therapy agents, for effective oncolytic activity, viruses need to specifically infect and effectively replicate in cancer cells but not in normal cells. We have previously identified a pancreatic cancer\u2010targeting ligand, <jats:styled-content style=\"fixed-case\">SYENFSA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">SYE<\/jats:styled-content>), by screening an adenovirus library displaying random peptides against human pancreatic cancer cells and reported that a survivin promoter\u2010regulated adenovirus, displaying the <jats:styled-content style=\"fixed-case\">SYE<\/jats:styled-content> ligand (AdSur\u2010<jats:styled-content style=\"fixed-case\">SYE<\/jats:styled-content>), provided effective oncolysis of pancreatic ductal adenocarcinoma (<jats:styled-content style=\"fixed-case\">PDAC<\/jats:styled-content>) in a preclinical study. As we examined the infectivity of AdSur\u2010<jats:styled-content style=\"fixed-case\">SYE<\/jats:styled-content> in human surgical specimens of various pancreatic tumors, we unexpectedly found that AdSur\u2010<jats:styled-content style=\"fixed-case\">SYE<\/jats:styled-content> showed high gene transduction efficiency for pancreatic neuroendocrine tumors (<jats:styled-content style=\"fixed-case\">PNET<\/jats:styled-content>s) as well as for <jats:styled-content style=\"fixed-case\">PDAC<\/jats:styled-content>, 9.1\u2010 and 6.2\u2010fold, respectively, compared to that of the nontargeting virus (AdSur). The infectivity of both vectors was almost the same in other cancers and organs such as the pancreas. Immunostaining indicated that the cells infected with AdSur\u2010<jats:styled-content style=\"fixed-case\">SYE<\/jats:styled-content> were <jats:styled-content style=\"fixed-case\">PNET<\/jats:styled-content> cells but not stromal cells. AdSur\u2010<jats:styled-content style=\"fixed-case\">SYE<\/jats:styled-content> showed a significantly higher oncolytic potency than that of AdSur in human <jats:styled-content style=\"fixed-case\">PNET<\/jats:styled-content> cell lines, and intratumoral infection with AdSur\u2010<jats:styled-content style=\"fixed-case\">SYE<\/jats:styled-content> completely diminished subcutaneous tumors in a murine model, in which AdSur\u2010<jats:styled-content style=\"fixed-case\">SYE<\/jats:styled-content> effectively proliferated and spread. AdSur\u2010<jats:styled-content style=\"fixed-case\">SYE<\/jats:styled-content> exerted a stronger oncolytic effect in primary <jats:styled-content style=\"fixed-case\">PNET<\/jats:styled-content> cells cocultured with mouse embryonic fibroblasts than AdSur did. Thus, AdSur\u2010<jats:styled-content style=\"fixed-case\">SYE<\/jats:styled-content> shows promise as a next\u2010generation therapy for <jats:styled-content style=\"fixed-case\">PNET<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/cam4.1185","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T10:49:58Z","timestamp":1505990998000},"page":"2385-2397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Strong antitumor efficacy of a pancreatic tumor\u2010targeting oncolytic adenovirus for neuroendocrine tumors"],"prefix":"10.1002","volume":"6","author":[{"given":"Yuki","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Division of Molecular and Cellular Medicine National Cancer Center Research Institute  Tokyo Japan"},{"name":"NCC Cancer Science Tokyo Medical and Dental University  Tokyo 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