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Our results indicate that the profiles of <jats:styled-content style=\"fixed-case\">CML HSC<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">HPC<\/jats:styled-content>s were closer to that of normal progenitors, whereas normal <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>s showed the most different expression profile of all. We found that the expression profiles of <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">HPC<\/jats:styled-content>s from <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> marrow were closer to each other than those of <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">HPC<\/jats:styled-content>s from normal marrow. The major biologic processes dysregulated in <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> cells included <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> repair, cell cycle, chromosome condensation, cell adhesion, and the immune response. We also determined the genomic changes in both normal and <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> progenitor cells under culture conditions, and found that several genes involved in cell cycle, steroid biosynthesis, and chromosome segregation were upregulated, whereas genes involved in transcription regulation and apoptosis were downregulated. Interestingly, these changes were the same, regardless of the addition of Imatinib (<jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>) to the culture. Finally, we identified three genes\u2014<jats:styled-content style=\"fixed-case\">PIEZO<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">RXFP<\/jats:styled-content>1, and <jats:styled-content style=\"fixed-case\">MAMDC<\/jats:styled-content>2\u2010 that are preferentially expressed by <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> primitive cells and that encode for cell membrane proteins; thus, they could be used as biomarkers for <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> stem cells.<\/jats:p>","DOI":"10.1002\/cam4.1187","type":"journal-article","created":{"date-parts":[[2017,10,14]],"date-time":"2017-10-14T04:08:55Z","timestamp":1507954135000},"page":"2942-2956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Global gene expression profiles of hematopoietic stem and progenitor cells from patients with chronic myeloid leukemia: the effect of in vitro culture with or without imatinib"],"prefix":"10.1002","volume":"6","author":[{"given":"S\u00f3crates","family":"Avil\u00e9s\u2010V\u00e1zquez","sequence":"first","affiliation":[{"name":"Oncology Research Unit Oncology Hospital National Medical Center Mexican Institute for Social Security  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonieta","family":"Ch\u00e1vez\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Oncology Research Unit Oncology Hospital National Medical Center Mexican Institute for Social Security  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Hidalgo\u2010Miranda","sequence":"additional","affiliation":[{"name":"National Institute of Genomic Medicine  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafne","family":"Moreno\u2010Lorenzana","sequence":"additional","affiliation":[{"name":"Oncology Research Unit 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