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To investigate the Doppler ultrasound (DUS<\/jats:styled-content>)\u2010CRT<\/jats:styled-content> incidence, risk factors and outcomes in BC<\/jats:styled-content>, we designed a prospective, multicenter cohort of nonmetastatic invasive BC<\/jats:styled-content> patients undergoing insertion of a CVC<\/jats:styled-content> for chemotherapy. All patients underwent double\u2010blind DUS<\/jats:styled-content> before, 7, 30, and 90\u00a0days after CVC<\/jats:styled-content> insertion and a 6\u00a0months clinical follow\u2010up. Symptomatic DUS<\/jats:styled-content>\u2010CRT<\/jats:styled-content> were treated by anticoagulants. D\u2010Dimers, thrombin generation, and platelet\u2010derived microparticles were measured before and 2\u00a0days after CVC<\/jats:styled-content> placement. In DUS<\/jats:styled-content>\u2010CRT<\/jats:styled-content> patients, a nested case\u2013control study analyzed the role of thrombophilia. Among 524 patients, the DUS<\/jats:styled-content>\u2010CRT<\/jats:styled-content> (14 symptomatic, 46 asymptomatic) cumulative probability was 9.6% at 3\u00a0months and 11.5% at 6\u00a0months (overall incidence rate: 2.18\/100 patient\u2010months). Ten\/14 symptomatic DUS<\/jats:styled-content>\u2010CRT<\/jats:styled-content> were detected on double\u2010blind DUS<\/jats:styled-content> before the clinical symptoms, and 3\/14 had a simultaneous pulmonary embolism. No clinical thrombotic event subsequently occurred in untreated asymptomatic DUS<\/jats:styled-content>\u2010CRT<\/jats:styled-content>. Age >50\u00a0years (OR<\/jats:styled-content>, 1.80; 95% CI<\/jats:styled-content>, 1.01\u20133.22), BMI >30\u00a0kg\/m\u00b2 (OR<\/jats:styled-content>, 2.64; 95% CI<\/jats:styled-content>, 1.46\u20134.76) and comorbidities (OR<\/jats:styled-content>, 2.05; 95% CI<\/jats:styled-content>, 1.18\u20133.56) were associated with DUS<\/jats:styled-content>\u2010CRT<\/jats:styled-content>. No biomarkers was found to predict DUS<\/jats:styled-content>\u2010CRT<\/jats:styled-content>. In multivariate analysis, BMI >30\u00a0kg\/m\u00b2 (OR<\/jats:styled-content>, 2.66; 95%CI<\/jats:styled-content>, 1.46\u20134.84) and lobular carcinoma histology (OR<\/jats:styled-content>, 2.56; 95%CI<\/jats:styled-content>, 1.32\u20134.96) remained the only significant DUS<\/jats:styled-content>\u2010CRT<\/jats:styled-content> risk factors. Thrombophilia did not account for DUS<\/jats:styled-content>\u2010CRT<\/jats:styled-content>. Only clinical parameters identified high risk DUS<\/jats:styled-content>\u2010CRT<\/jats:styled-content> patients who may be considered for thromboprophylaxis.<\/jats:p>","DOI":"10.1002\/cam4.1201","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T02:32:40Z","timestamp":1507170760000},"page":"2732-2744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Incidence, risk factors, and outcomes of central venous catheter\u2010related thromboembolism in breast cancer patients: the CAVECCAS<\/scp> study"],"prefix":"10.1002","volume":"6","author":[{"given":"Philippe","family":"Debourdeau","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Sainte Catherine Institute Avignon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Espi\u00e9","sequence":"additional","affiliation":[{"name":"Breast Cancer Unit Saint Louis Hospital Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"},{"name":"University Paris Diderot Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Chevret","sequence":"additional","affiliation":[{"name":"University Paris Diderot Paris France"},{"name":"Biostatistic Department and Medical Informatics Saint\u2010Louis Hospital Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Gligorov","sequence":"additional","affiliation":[{"name":"Medical Oncology Tenon Hospital Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"},{"name":"Francilian Breast Intergroup, APREC IUC\u2010UPMC Sorbonne University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine Sainte Musse Hospital Toulon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre Fran\u00e7ois","family":"Dupr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Surgery CHRU Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristell","family":"Desseaux","sequence":"additional","affiliation":[{"name":"University Paris Diderot Paris France"},{"name":"Biostatistic Department and Medical Informatics Saint\u2010Louis Hospital Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issa","family":"Kalidi","sequence":"additional","affiliation":[{"name":"Department of Biology Saint Louis Hospital Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Villiers","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation Saint Louis Hospital Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Giachetti","sequence":"additional","affiliation":[{"name":"Breast Cancer Unit Saint Louis Hospital Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"},{"name":"University Paris Diderot Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6303-4732","authenticated-orcid":false,"given":"Corinne","family":"Frere","sequence":"additional","affiliation":[{"name":"Department of Haematology Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"},{"name":"Sorbonne Universit\u00e9s UPMC Universit\u00e9 Paris 06, UMR_S 1166 Paris France"},{"name":"Institute of Cardiometabolism and Nutrition, ICAN Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Farge","sequence":"additional","affiliation":[{"name":"University Paris Diderot Paris France"},{"name":"Internal Medicine Unit: Autoimmune and Vascular Diseases, UF 04 Saint\u2010Louis Hospital, Assistance Publique\u2010H\u00f4pitaux de Paris, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,4]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Breast Cancer Statistics | World Cancer Research Fund International. 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