{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:33:47Z","timestamp":1786977227255,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Abstract<\/jats:title>\n \n Several studies have reported uneven results when evaluating the prognostic value of bone marrow biopsy (\n BMB<\/jats:styled-content>\n ) and\n PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n as part of the staging of diffuse large B\u2010cell lymphoma (\n DLBCL<\/jats:styled-content>\n ). The heterogeneity of the inclusion criteria and not taking into account selection and collinearity biases in the analysis models might explain part of these discrepancies. To address this issue we have carried a retrospective multicenter study including 268\n DLBCL<\/jats:styled-content>\n patients with a\n BMB<\/jats:styled-content>\n and a\n PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n available at diagnosis where we estimated both the prognosis impact and the diagnostic accuracy of each technique. Only patients treated with R\u2010\n CHOP<\/jats:styled-content>\n \/21 as first line (\n n<\/jats:italic>\n \u00a0=\u00a0203) were included in the survival analysis. With a median follow\u2010up of 25\u00a0months the estimated 3\u2010year progression\u2010free survival (\n PFS<\/jats:styled-content>\n ) and overall survival (\n OS<\/jats:styled-content>\n ) were 76.3% and 82.7% respectively. In a multivariate analysis designed to avoid a collinearity bias with\n IPI<\/jats:styled-content>\n categories,\n BMB<\/jats:styled-content>\n \u2010\n BMI<\/jats:styled-content>\n [bone marrow involvement](+) (\n HR<\/jats:styled-content>\n : 3.6) and\n ECOG PS<\/jats:styled-content>\n \u00a0>\u00a01 (\n HR<\/jats:styled-content>\n : 2.9) were independently associated with a shorter\n PFS<\/jats:styled-content>\n and three factors, age >60\u00a0years old (\n HR<\/jats:styled-content>\n : 2.4),\n ECOG PS<\/jats:styled-content>\n \u00a0>1 (\n HR<\/jats:styled-content>\n : 2.4), and abnormally elevated B2\u2010microglobulin levels (\n HR<\/jats:styled-content>\n : 2.2) were independently associated with a shorter\n OS<\/jats:styled-content>\n . In our\n DLBCL<\/jats:styled-content>\n cohort, treated with a uniform first\u2010line chemotherapy regimen,\n BMI<\/jats:styled-content>\n by\n BMB<\/jats:styled-content>\n complemented performance status in predicting those patients with a higher risk for relapse or progression. In this cohort\n BMI<\/jats:styled-content>\n by\n PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n could not independently predict a shorter\n PFS<\/jats:styled-content>\n and\/or\n OS<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1002\/cam4.1205","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T11:49:49Z","timestamp":1506599389000},"page":"2507-2514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Bone marrow biopsy superiority over\n PET<\/scp>\n \/\n CT<\/scp>\n in predicting progression\u2010free survival in a homogeneously\u2010treated cohort of diffuse large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"6","author":[{"given":"Tzu\u2010Hua","family":"Chen\u2010Liang","sequence":"first","affiliation":[{"name":"Servicio de Hematolog\u00eda y Oncolog\u00eda M\u00e9dica. H.J.M. Morales Meseguer IMIB\u2010Arrixaca Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taida","family":"Mart\u00edn\u2010Santos","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. Universitario de Canarias La Laguna Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2079-6638","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Jerez","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda y Oncolog\u00eda M\u00e9dica. H.J.M. Morales Meseguer IMIB\u2010Arrixaca Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Rodr\u00edguez\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. Virgen del Rocio Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"Senent","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mart\u00ednez\u2010Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. Sta. Lucia Cartagena Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Mui\u00f1a","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. R. M\u00e9ndez Lorca Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayte","family":"Orero","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. General Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anabel","family":"Teruel","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda y Oncolog\u00eda M\u00e9dica. H. Cl\u00ednico Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. Cl\u00ednico Universitario de Salamanca\/IBSAL Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"G\u00f3mez\u2010Espuch","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. Virgen de la Arrixaca Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyra","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. Ramon y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Benet","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. Arnau de Vilanova Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Raya","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. Universitario de Canarias La Laguna Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Fern\u00e1ndez\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. Universitario de Canarias La Laguna Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima","family":"de la Cruz","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. Virgen del Rocio Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Guinot","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Villegas","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. General Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Ballester","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda y Oncolog\u00eda M\u00e9dica. H. Cl\u00ednico Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Baile","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. Cl\u00ednico Universitario de Salamanca\/IBSAL Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Moya","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. Virgen de la Arrixaca Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"L\u00f3pez\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda. H. Ramon y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Frutos","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Nuclear. H. Virgen de la Arrixaca Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Navarro","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Nuclear. H. Virgen de la Arrixaca Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"U\u00f1a","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Nuclear. H. Universitario N.S. de la Candelaria Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Fern\u00e1ndez\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Nuclear. H\u2010 Virgen del Rocio Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Igua","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Nuclear. H. La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Contreras","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Nuclear. H. Sta Lucia Cartagena Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"S\u00e1nchez\u2010Va\u00f1\u00f3","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Nuclear. H. 9 de Octubre Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Puig","family":"Cozar","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Nuclear. H. General\u2010ERESA Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Tamayo","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Nuclear. H. Cl\u00ednico Universitario de Salamanca\/IBSAL Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Mucientes","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Nuclear. H. Puerta de Hierro Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Javier","family":"S\u00e1nchez\u2010Blanco","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda y Oncolog\u00eda M\u00e9dica. H.J.M. Morales Meseguer IMIB\u2010Arrixaca Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"P\u00e9rez\u2010Ceballos","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda y Oncolog\u00eda M\u00e9dica. H.J.M. Morales Meseguer IMIB\u2010Arrixaca Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Jos\u00e9","family":"Ortu\u00f1o","sequence":"additional","affiliation":[{"name":"Servicio de Hematolog\u00eda y Oncolog\u00eda M\u00e9dica. H.J.M. Morales Meseguer IMIB\u2010Arrixaca Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"issue":"10","key":"e_1_2_6_2_1","first-page":"2","article-title":"The role of FDG\u2010PET and bone marrow examination in lymphoma staging","volume":"23","author":"El\u2010Najjar I.","year":"2012","journal-title":"Ann. 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J. Nucl. Med. Mol. Imaging"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-011-1353-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14071"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.5229"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8800"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23730"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.70.4890"},{"key":"e_1_2_6_21_1","article-title":"Overestimated value of FDG\u2010PET based bone marrow evaluation in lymphoma: response to Adams and Kwee","author":"Ujjani C. S.","year":"2016","journal-title":"Br. J. Haematol."},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2710-2"},{"key":"e_1_2_6_23_1","volume-title":"Multivariate data analysis","author":"Hair J. F.","year":"1998"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24061"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.1205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.1205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T05:35:55Z","timestamp":1695706555000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.1205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,27]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/cam4.1205"],"URL":"https:\/\/doi.org\/10.1002\/cam4.1205","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,27]]},"assertion":[{"value":"2017-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}