{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:06:47Z","timestamp":1787954807807,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T00:00:00Z","timestamp":1506297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the present study was to determine whether or not the overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) and disease\u2010free survival (<jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content>) were affected by the tumor location in patients who underwent curative resection for colon cancer in a pooled analysis of three large phase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> studies performed in Japan. In total, 4029 patients were included in the present study. Patients were classified as having right\u2010side colon cancer (<jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>) if the primary tumor was located in the cecum, ascending colon, hepatic flexure or transverse colon, and left\u2010side colon cancer (<jats:styled-content style=\"fixed-case\">LCC<\/jats:styled-content>) if the tumor site was within the splenic flexure, descending colon, sigmoid colon or recto sigmoid junction. The risk factors for the <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content> were analyzed. In the present study, 1449 patients were <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content>, and 2580 were <jats:styled-content style=\"fixed-case\">LCC<\/jats:styled-content>. The <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> rates at 3 and 5\u00a0years after surgery were 87.6% and 81.6% in the <jats:styled-content style=\"fixed-case\">RC<\/jats:styled-content> group and 91.5% and 84.5% in the <jats:styled-content style=\"fixed-case\">LCC<\/jats:styled-content> group, respectively. Uni\u2010 and multivariate analyses showed that <jats:styled-content style=\"fixed-case\">RRC<\/jats:styled-content> increased the risk of death by 19.7% (adjusted hazard ratio\u00a0=\u00a01.197; 95% confidence interval, 1.020\u20131.408; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0272). In contrast, the <jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content> was similar between the two locations. The present study confirmed that the tumor location was a risk factor for the <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> in patients who underwent curative treatment for colon cancer. Tumor location may, therefore, need to be considered a stratification factor in future phase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> trials of colon cancer.<\/jats:p>","DOI":"10.1002\/cam4.1208","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T04:06:45Z","timestamp":1506398805000},"page":"2523-2530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Clinical impact of tumor location on the colon cancer survival and recurrence: analyses of pooled data from three large phase <scp>III<\/scp> randomized clinical trials"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6803-3800","authenticated-orcid":false,"given":"Toru","family":"Aoyama","sequence":"first","affiliation":[{"name":"Department of Surgery Yokohama City University  Yokohama 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