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The aim of the study is to create and validate a questionnaire to identify individuals with possible risk for hereditary cancer predisposition syndromes (HCPS), using different strategies in a Cancer Prevention Service in Brazil. The primary screening questionnaire (PSQ) was developed to identify families at\u2010risk for HCPS. The PSQ was validated using discrimination measures, and the reproducibility was estimated through kappa coefficient. Patients with at least one affirmative answer had the pedigree drawn using three alternative interview approaches: in\u2010person, by telephone, or letter. Validation of these approaches was done. Kappa and intraclass correlation coefficients were used to analyze data's reproducibility considering the presence of clinical criteria for HCPS. The PSQ was applied to a convenience sample of 20,000 women of which 3121 (15.6%) answered at least one affirmative question and 1938 had their pedigrees drawn. The PSQ showed sensitivity and specificity scores of 94.4% and 75%, respectively, and a kappa of 0.64. The strategies for pedigree drawing had reproducibility coefficients of 0.976 and 0.850 for the telephone and letter approaches, respectively. Pedigree analysis allowed us to identify 465 individuals (24.0%) fulfilling at least one clinical criterion for HCPS. The PSQ fulfills its function, allowing the identification of HCPS at\u2010risk families. The use of alternative screening methods may reduce the number of excluded at\u2010risk individuals\/families who live in locations where oncogenetic services are not established.<\/jats:p>","DOI":"10.1002\/cam4.1210","type":"journal-article","created":{"date-parts":[[2017,10,22]],"date-time":"2017-10-22T04:06:39Z","timestamp":1508645199000},"page":"3014-3024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Identification of hereditary cancer in the general population: development and validation of a screening questionnaire for obtaining the family history of cancer"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6063-3254","authenticated-orcid":false,"given":"Natalia","family":"Campacci","sequence":"first","affiliation":[{"name":"Molecular Oncology Research Center Barretos Cancer Hospital  Barretos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana O.","family":"de Lima","sequence":"additional","affiliation":[{"name":"Center of Molecular Diagnostics Barretos Cancer Hospital  Barretos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 L.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center Barretos Cancer Hospital  Barretos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo D.","family":"Michelli","sequence":"additional","affiliation":[{"name":"Oncogenetics Department Barretos Cancer Hospital  Barretos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Rafael","family":"Haikel","sequence":"additional","affiliation":[{"name":"Prevention Department Barretos Cancer Hospital  Barretos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmundo","family":"Mauad","sequence":"additional","affiliation":[{"name":"Oncogenetics Department Barretos Cancer Hospital  Barretos Brazil"},{"name":"Prevention Department Barretos Cancer Hospital  Barretos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo V.","family":"Viana","sequence":"additional","affiliation":[{"name":"Oncogenetics Department Barretos Cancer Hospital  Barretos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matias E.","family":"Melendez","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center Barretos Cancer Hospital  Barretos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana de L.","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center Barretos Cancer Hospital  Barretos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleyton","family":"Zanardo","sequence":"additional","affiliation":[{"name":"Center for Research Support \u2013 NAP Barretos Cancer Hospital  Barretos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui M.","family":"Reis","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center Barretos Cancer Hospital  Barretos Brazil"},{"name":"Center of Molecular Diagnostics Barretos Cancer Hospital  Barretos Brazil"},{"name":"Life and Health Sciences Institute (ICVS) School of Medicine University of Minho Campus Gualtar, Braga, Portugal; 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