{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:00:15Z","timestamp":1792432815042,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T00:00:00Z","timestamp":1507075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Abstract<\/jats:title>\n \n Programmed cell death\u20101 (\n PD<\/jats:styled-content>\n \u20101) and programmed cell death\u2010ligand 1 (\n PD<\/jats:styled-content>\n \u2010L1) have been identified as novel targets of immunotherapy of lung cancer. In present study, we evaluated the metabolic characteristics of lung cancer by using\n 18<\/jats:sup>\n F\u2010fluorodeoxyglucose positron emission tomography\/computed tomography (\n 18<\/jats:sup>\n F\u2010\n FDG PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n ) with regard to\n PD<\/jats:styled-content>\n \u2010L1 protein expression.\n PD<\/jats:styled-content>\n \u2010L1 protein expression was evaluated by immunohistochemistry with the antibody clone\n SP<\/jats:styled-content>\n 142 in 579 surgically resected primary lung cancer patients. Cases with less than 5% tumor membrane staining were considered negative. We examined the association between the frequency of\n PD<\/jats:styled-content>\n \u2010L1 protein expression and the maximum standardized uptake value (\n SUV<\/jats:styled-content>\n max) in preoperative\n 18<\/jats:sup>\n F\u2010\n FDG PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n . The cut\u2010off values for\n SUV<\/jats:styled-content>\n max were determined by receiver operating characteristic curve analyses. The\n SUV<\/jats:styled-content>\n max was significantly higher in nonsmall cell lung cancer (\n NSCLC<\/jats:styled-content>\n ) patients with\n PD<\/jats:styled-content>\n \u2010L1 protein expression compared with those without\n PD<\/jats:styled-content>\n \u2010L1 protein expression (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.0001). However, there was no correlation between\n SUV<\/jats:styled-content>\n max and\n PD<\/jats:styled-content>\n \u2010L1 protein expression in patients with neuroendocrine tumors (\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.6545). Multivariate analysis revealed that smoking, the presence of pleural invasion, and high\n SUV<\/jats:styled-content>\n max were independent predictors of\n PD<\/jats:styled-content>\n \u2010L1 positivity.\n PD<\/jats:styled-content>\n \u2010L1\u2010expressing\n NSCLC<\/jats:styled-content>\n had a high glucose metabolism. The\n SUV<\/jats:styled-content>\n max in preoperative\n 18<\/jats:sup>\n F\u2010\n FDG PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n was a predictor of\n PD<\/jats:styled-content>\n \u2010L1 protein expression in patients with\n NSCLC<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1002\/cam4.1215","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T22:08:42Z","timestamp":1507154922000},"page":"2552-2561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Metabolic characteristics of programmed cell death\u2010ligand 1\u2010expressing lung cancer on\n 18<\/sup>\n F\u2010fluorodeoxyglucose positron emission tomography\/computed tomography"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6377-9291","authenticated-orcid":false,"given":"Kazuki","family":"Takada","sequence":"first","affiliation":[{"name":"Department of Surgery and 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