{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:40:12Z","timestamp":1740166812102,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>Overall survival (OS<\/jats:styled-content>) is the gold\u2010standard end point for studies evaluating autologous stem cell transplantation (ASCT<\/jats:styled-content>) in follicular lymphoma (FL<\/jats:styled-content>), but assessment may be elusive due to the lengthy disease course. We analyzed the validity of two earlier end points, proposed in the setting of first\u2010line chemo\u2010\/immunotherapy, as surrogates for OS<\/jats:styled-content>\u2014progression\u2010free survival (PFS<\/jats:styled-content>) status at 24\u00a0months (PFS<\/jats:styled-content>24) and complete response at 30\u00a0months (CR<\/jats:styled-content>30) post\u2010ASCT<\/jats:styled-content>. We also have investigated the clinical features of patients with early progression after ASCT<\/jats:styled-content>. Data were available for 626 chemosensitive FL<\/jats:styled-content> patients who received ASCT<\/jats:styled-content> between 1989 and 2007. Median follow\u2010up was 12.2\u00a0years from ASCT<\/jats:styled-content>. In the PFS<\/jats:styled-content>24 analysis, 153 (24%) patients progressed within 24\u00a0months and 447 were alive and progression\u2010free at 24\u00a0months post\u2010ASCT<\/jats:styled-content> (26 who died without disease progressions within 24\u00a0months were excluded). Early progression was associated with shorter OS<\/jats:styled-content> (hazard ratio [HR<\/jats:styled-content>], 6.8; P\u00a0<\/jats:italic>=\u00a00.00001). In the subgroup of patients who received an ASCT<\/jats:styled-content> in the setting or relapse after being exposed to rituximab, the HR<\/jats:styled-content> was 11.3 (95% CI<\/jats:styled-content>, 3.9\u201330.2; P\u00a0<\/jats:italic><\u00a00.00001). In the CR<\/jats:styled-content>30 analysis, 183 of 596 (31%) response\u2010evaluable patients progressed\/died with 30\u00a0months post\u2010ASCT<\/jats:styled-content>. The absence of CR<\/jats:styled-content>30 was associated with shorter OS<\/jats:styled-content> (HR<\/jats:styled-content>, 7.8; P<\/jats:italic>\u00a0<\u00a00.00001), including in patients with prior rituximab (HR<\/jats:styled-content>, 8.2). PFS<\/jats:styled-content>24 and CR<\/jats:styled-content>30 post\u2010ASCT<\/jats:styled-content> are associated with poor outcomes and should be primary end points. Further research is needed to identify this population to be offered alternative treatments.<\/jats:p>","DOI":"10.1002\/cam4.1217","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T04:08:48Z","timestamp":1509077328000},"page":"2766-2774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Progression\u2010free survival at 2\u00a0years post\u2010autologous transplant: a surrogate end point for overall survival in follicular lymphoma"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0892-8682","authenticated-orcid":false,"given":"Ana","family":"Jim\u00e9nez\u2010Ubieto","sequence":"first","affiliation":[{"name":"Hospital Universitario 12 de Octubre Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Grande","sequence":"additional","affiliation":[{"name":"Hospital Universitario 12 de Octubre Madrid 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