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Precancerous colorectal lesions also contain many of these same mutations. This study examined plasma for ct<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> from patients undergoing a screening or diagnostic colonoscopy to determine the sensitivity and specificity of the ct<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> panel for detecting <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> and precancerous lesions. Two hundred patients without a history of nonskin cancer had blood drawn before a colonoscopy. Plasma ct<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was measured with a 96 mutation panel for nine cancer driver genes. The ct<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> results were correlated with the findings at colonoscopy. Of the 200 patients, 176 (88%) had wild\u2010type <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>, 12 (6%) had mutations detected, and 12 (6%) had indeterminate results. Colonoscopy was normal in 80% of the patients and 20% were found to have polyps. No <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> was found in this study, precluding a determination of true\u2010positive rate for <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> detection. Our ct<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> panel was positive in 13.2% of patients with colonic polyps found at colonoscopy, while 4.7% of patients with normal colonoscopy also had ct<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> detected, which may represent ct<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> released from a benign process, an occult tumor, or an acquired somatic mutation from clonal hematopoiesis.<\/jats:p>","DOI":"10.1002\/cam4.1249","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T11:42:36Z","timestamp":1510314156000},"page":"167-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Tumor\u2010associated <scp>DNA<\/scp> mutation detection in individuals undergoing colonoscopy"],"prefix":"10.1002","volume":"7","author":[{"given":"Phillip","family":"Fleshner","sequence":"first","affiliation":[{"name":"Division of Colorectal Surgery Cedars\u2010Sinai Medical Center  Los Angeles California 90048"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5568-1662","authenticated-orcid":false,"given":"Glenn D.","family":"Braunstein","sequence":"additional","affiliation":[{"name":"Pathway Genomics  San Diego California 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayane","family":"Ovsepyan","sequence":"additional","affiliation":[{"name":"Division of Colorectal Surgery Cedars\u2010Sinai Medical Center  Los Angeles California 90048"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa R.","family":"Tonozzi","sequence":"additional","affiliation":[{"name":"Pathway Genomics  San Diego California 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Kammesheidt","sequence":"additional","affiliation":[{"name":"Pathway Genomics  San Diego California 92121"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,10]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"American Cancer Society.Key Statistics for Colorectal Cancer.2017. 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