{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:38:44Z","timestamp":1770824324857,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T00:00:00Z","timestamp":1511481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009925","name":"Villadsen Family Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009925","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Candy\u2019s Foundation"},{"name":"Kraeftfonden (The Cancer Foundation)"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Identifying the causes of death in head and neck cancer patients can optimize follow\u2010up and therapeutic strategies, but studies in oropharyngeal squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">OPSCC<\/jats:styled-content>) patients stratified by <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> status are lacking. We report cause\u2010specific mortality in a population\u2010based cohort of patients with <jats:styled-content style=\"fixed-case\">OPSCC<\/jats:styled-content>. Patients who had been diagnosed with <jats:styled-content style=\"fixed-case\">OPSCC<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a01541) between 2000 and 2014 in eastern Denmark were included in the study. Causes of death were collected through medical files and the Danish National Cause of Death registry. Deaths were grouped as (1) primary oropharyngeal cancer, (2) secondary malignancies, (3) cardiovascular and pulmonary disease, or (4) other\/unspecified. The cumulative incidence of death and specific causes of death were determined using risk analysis. At follow\u2010up, 723 (47.5%) patients had died. The median time to and cause of death were determined: oropharyngeal cancer (<jats:italic>n<\/jats:italic>\u00a0=\u00a0432; 1.00\u00a0year), secondary malignancies (<jats:italic>n<\/jats:italic>\u00a0=\u00a0131; 2.37\u00a0years), cardiovascular and pulmonary causes (<jats:italic>n<\/jats:italic>\u00a0=\u00a058; 3.48\u00a0years), and unspecified causes (<jats:italic>n<\/jats:italic>\u00a0=\u00a0102; 3.42\u00a0years). <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\/p16 status was the strongest predictor of improved survival across all causes of death. The only cause of death to decrease in incidence over the 2\u00a0years after treatment was death from <jats:styled-content style=\"fixed-case\">OPSCC<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\/p16 positivity was an independent factor for improved survival across all causes of death in patients with <jats:styled-content style=\"fixed-case\">OPSCC<\/jats:styled-content>. In addition, both <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010positive and HPV\u2010negative <jats:styled-content style=\"fixed-case\">OPSCC<\/jats:styled-content> patients faced high 5\u2010 and 10\u2010year mortality rates. Implementing secondary screening and prevention strategies for late toxicity and mortality are major goals in managing the treatment of these patients.<\/jats:p>","DOI":"10.1002\/cam4.1264","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T05:06:35Z","timestamp":1511499995000},"page":"87-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cause\u2010specific mortality in <scp>HPV<\/scp>+ and <scp>HPV<\/scp>\u2212 oropharyngeal cancer patients: insights from a population\u2010based cohort"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9438-4986","authenticated-orcid":false,"given":"Cecilie","family":"N\u00f8rregaard","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Gr\u00f8nh\u00f8j","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeppe","family":"Friborg","sequence":"additional","affiliation":[{"name":"Department of Oncology Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elo","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Oncology Herlev Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"von Buchwald","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25699"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.10.015"},{"issue":"9","key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1002\/ijc.29254","article-title":"A high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, 2000\u20102010: the largest registry\u2010based study to date","volume":"136","author":"Garnaes E.","year":"2014","journal-title":"Int. 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