{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:40:11Z","timestamp":1790232011952,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T00:00:00Z","timestamp":1514246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Proj.N.Y20170119"],"award-info":[{"award-number":["Proj.N.Y20170119"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The existence of Th17 cells and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 was recently shown in several types of infectious diseases, but their distribution and functions in cervical lesions with high\u2010risk human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) infection have not been fully elucidated. In this study, the frequency of Th17 cells in peripheral blood samples obtained from 28 cervical squamous cell carcinoma patients, 26 <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>1 patients, 30 <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2 patients, 29 <jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>3 patients, 25 high\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010infected women with normal cervical cytology, and 30 healthy controls was determined by flow cytometry. Besides, the levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 in peripheral blood samples as well as in supernatant of cervical tissue homogenate were assessed by enzyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>) simultaneously. We found that during the disease progression of cervical lesions, the proportion of Th17 cells in the total <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> cells showed a gradually increased tendency compared with the controls (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Moreover, levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 in serum and supernatant of cervical tissue homogenate showed the same tendency as the proportion of Th17 cells (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). When compared in pairs, the levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 in supernatant differed significantly among the study groups and the control group (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05), but no significant difference was observed in serum (<jats:italic>P\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.05). In conclusions, the results indicate that Th17 cells and IL\u201017 may play a role of immune enhancement in the infection of high\u2010risk HPV especially in the cervical microenvironment, which contribute to the disease progression of its associated cervical lesions.<\/jats:p>","DOI":"10.1002\/cam4.1279","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T05:02:47Z","timestamp":1514264567000},"page":"297-306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Effects of Th17 cells and <scp>IL<\/scp>\u201017 in the progression of cervical carcinogenesis with high\u2010risk human papillomavirus infection"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1381-8920","authenticated-orcid":false,"given":"JiSen","family":"Xue","sequence":"first","affiliation":[{"name":"The Department of Gynecology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 325000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8428-4204","authenticated-orcid":false,"given":"YuLi","family":"Wang","sequence":"additional","affiliation":[{"name":"The Department of Gynecology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 325000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"The Department of Gynecology The Second Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 325000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XueJie","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Department of Gynecology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 325000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Department of Gynecology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 325000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3566-1197","authenticated-orcid":false,"given":"Yan","family":"Hu","sequence":"additional","affiliation":[{"name":"The Department of Gynecology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang 325000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.10.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6317"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0498-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1062209"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1085"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1261"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2015.07.006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0742-y"},{"key":"e_1_2_6_12_1","article-title":"Innate\u2010like function of memory Th17 cells for enhancing endotoxin\u2010induced acute lung inflammation through IL\u201022","author":"Sakaguchi R.","year":"2015","journal-title":"Int. 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