{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:53:33Z","timestamp":1761519213261,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As diagnostic and therapeutic modalities for Hodgkin's Lymphoma (<jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>) continue to improve, patient\u2010related factors affecting survival become more difficult to identify. Very little is known about the relationship between the primary site of lymph node (<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>) involvement and survival of <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> patients. We retrospectively analyzed the United States Surveillance, Epidemiology and End Results (<jats:styled-content style=\"fixed-case\">SEER<\/jats:styled-content>) database for 12,658 <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> patients reported between 1973 and 2010 using survival analysis and time\u2010interval multiple logistic regression (<jats:styled-content style=\"fixed-case\">MLR<\/jats:styled-content>) to disclose that relationship. The effect of all primary <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> sites on the survival of <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content> patients was supported. The intra\u2010abdominal (<jats:styled-content style=\"fixed-case\">IAB<\/jats:styled-content>) primary <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> site was significantly associated with the worst survival. The pelvic (P) <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> sites were significantly and independently associated with nearly 2 times and 2.5 times the probability of having 1\u2010year overall mortality (<jats:styled-content style=\"fixed-case\">OM<\/jats:styled-content>) and 1\u2010year cancer\u2010specific mortality (<jats:styled-content style=\"fixed-case\">CSM<\/jats:styled-content>), respectively. Head, face and neck (<jats:styled-content style=\"fixed-case\">HFN<\/jats:styled-content>) primary <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> sites were significant and independent predictors of better overall and <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>\u2010specific survival. A worse survival with the intra\u2010abdominal primary <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> site was probably related to their association with higher age, or advanced stages of <jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>. The biological basis behind the aggressiveness of intra\u2010abdominal and pelvic <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> sites is yet to be investigated.<\/jats:p>","DOI":"10.1002\/cam4.1280","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T05:08:50Z","timestamp":1520572130000},"page":"953-965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The role of primary lymph node sites in survival and mortality prediction in Hodgkin lymphoma: a SEER population\u2010based retrospective study"],"prefix":"10.1002","volume":"7","author":[{"given":"Amr","family":"Ebied","sequence":"first","affiliation":[{"name":"Egyptian National Blood Transfusion Services  Cairo Egypt"},{"name":"Online Research Club (http:\/\/www.onlineresearchclub.org\/)  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vuong","family":"Thanh Huan","sequence":"additional","affiliation":[{"name":"Online Research Club (http:\/\/www.onlineresearchclub.org\/)  Nagasaki Japan"},{"name":"Pham Ngoc Thach University of Medicine  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar Mohamed","family":"Makram","sequence":"additional","affiliation":[{"name":"Online Research Club (http:\/\/www.onlineresearchclub.org\/)  Nagasaki Japan"},{"name":"Faculty of Medicine October 6 University  Giza 12566 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"To Kim","family":"Sang","sequence":"additional","affiliation":[{"name":"Online Research Club (http:\/\/www.onlineresearchclub.org\/)  Nagasaki Japan"},{"name":"Ho Chi Minh City Oncology Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Ghorab","sequence":"additional","affiliation":[{"name":"Online Research Club (http:\/\/www.onlineresearchclub.org\/)  Nagasaki Japan"},{"name":"Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huyen Thi","family":"Ngo","sequence":"additional","affiliation":[{"name":"Online Research Club (http:\/\/www.onlineresearchclub.org\/)  Nagasaki Japan"},{"name":"University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Iraqi","sequence":"additional","affiliation":[{"name":"Online Research Club (http:\/\/www.onlineresearchclub.org\/)  Nagasaki Japan"},{"name":"Cairo University Hospitals  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Gomaa","family":"Kamel","sequence":"additional","affiliation":[{"name":"Online Research Club (http:\/\/www.onlineresearchclub.org\/)  Nagasaki Japan"},{"name":"Faculty of Medicine Minia University  Minia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Ngoc","family":"Dang","sequence":"additional","affiliation":[{"name":"Online Research Club (http:\/\/www.onlineresearchclub.org\/)  Nagasaki Japan"},{"name":"University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Lam","family":"Vuong","sequence":"additional","affiliation":[{"name":"Online Research Club (http:\/\/www.onlineresearchclub.org\/)  Nagasaki Japan"},{"name":"University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Immunogenetics Institute of Tropical Medicine (NEKKEN) Graduate School of Biomedical Sciences Nagasaki University  1\u201012\u20104 Sakamoto Nagasaki 852\u20108523 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9543-9440","authenticated-orcid":false,"given":"Nguyen Tien","family":"Huy","sequence":"additional","affiliation":[{"name":"Evidence Based Medicine Research Group &amp; Faculty of Applied Sciences Ton Duc Thang University  Ho Chi Minh City Vietnam"},{"name":"Department of Clinical Product Development Institute of Tropical Medicine (NEKKEN) Leading Graduate School Program, and Graduate School of Biomedical Sciences Nagasaki University  1\u201012\u20104 Sakamoto Nagasaki 852\u20108523 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,9]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.3322\/caac.20073"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.3322\/caac.21387"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1182\/asheducation-2009.1.523"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1200\/JCO.1989.7.11.1630"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1200\/JCO.2013.54.8800"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1093\/annonc\/mdt413"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.4084\/mjhid.2014.053"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1056\/NEJM199811193392104"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1182\/blood.V73.1.47.47"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.1182\/asheducation-2003.1.225"},{"unstructured":"Suggested Citations \u2010 SEER Datasets.https:\/\/seer.cancer.gov\/data\/citation.html. Accessed January 16 2017.","key":"e_1_2_7_12_1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.1182\/blood-2006-11-051672"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_1","DOI":"10.1182\/blood-2010-06-289561"},{"key":"e_1_2_7_15_1","first-page":"32","article-title":"Pure infradiaphragmatic Hodgkin's lymphoma. Clinical features, prognostic factor and comparison with supradiaphragmatic disease","volume":"91","author":"Vassilakopoulos T. P.","year":"2006","journal-title":"Haematologica"},{"doi-asserted-by":"publisher","key":"e_1_2_7_16_1","DOI":"10.1034\/j.1600-0609.2003.00108.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_17_1","DOI":"10.1080\/10428190500144847"},{"doi-asserted-by":"publisher","key":"e_1_2_7_18_1","DOI":"10.1016\/s0360-3016(01)01813-2"},{"doi-asserted-by":"publisher","key":"e_1_2_7_19_1","DOI":"10.1016\/j.ijrobp.2015.02.012"},{"doi-asserted-by":"publisher","key":"e_1_2_7_20_1","DOI":"10.1007\/s00277-011-1297-x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_21_1","DOI":"10.1007\/s12185-010-0533-9"},{"doi-asserted-by":"publisher","key":"e_1_2_7_22_1","DOI":"10.4103\/1119-3077.91752"},{"doi-asserted-by":"publisher","key":"e_1_2_7_23_1","DOI":"10.1182\/asheducation-2006.1.266"},{"doi-asserted-by":"publisher","key":"e_1_2_7_24_1","DOI":"10.1200\/JCO.1999.17.3.776"},{"doi-asserted-by":"publisher","key":"e_1_2_7_25_1","DOI":"10.1182\/blood-2011-01-293050"},{"doi-asserted-by":"publisher","key":"e_1_2_7_26_1","DOI":"10.1182\/blood-2016-01-643569"},{"doi-asserted-by":"publisher","key":"e_1_2_7_27_1","DOI":"10.1002\/cncr.21995"},{"doi-asserted-by":"publisher","key":"e_1_2_7_28_1","DOI":"10.1200\/JCO.2007.11.5477"},{"doi-asserted-by":"publisher","key":"e_1_2_7_29_1","DOI":"10.1200\/JCO.2001.19.3.727"},{"doi-asserted-by":"publisher","key":"e_1_2_7_30_1","DOI":"10.1309\/AJCPHXO5UGW2OELA"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.1280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.1280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T05:49:28Z","timestamp":1723096168000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.1280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,9]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1002\/cam4.1280"],"URL":"https:\/\/doi.org\/10.1002\/cam4.1280","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"type":"print","value":"2045-7634"},{"type":"electronic","value":"2045-7634"}],"subject":[],"published":{"date-parts":[[2018,3,9]]},"assertion":[{"value":"2017-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}