{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:53:53Z","timestamp":1791590033490,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T00:00:00Z","timestamp":1516147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Abstract<\/jats:title>We sought to evaluate whether preoperative anemia was an important determinant of survival in gastric cancer (GC<\/jats:styled-content>). A single institution cohort of 2163 GC<\/jats:styled-content> patients who underwent curative resection were retrospectively analyzed. Anemia was defined as a preoperative hemoglobin level <120\u00a0g\/L in males and <110\u00a0g\/L in females. Overall survival (OS<\/jats:styled-content>) was analyzed using the Kaplan\u2013Meier method, and a multivariate Cox proportional hazards model was performed to identify the independent prognostic factor. Anemic patients had a poorer OS<\/jats:styled-content> compared with nonanemic patients after resection for tumor\u2013nodes\u2013metastasis (TNM<\/jats:styled-content>) stage III<\/jats:styled-content> tumors (5\u2010year OS<\/jats:styled-content> rate: 32.2% vs. 45.7%, P<\/jats:italic>\u2009<\u20090.001) but not stage I (P<\/jats:italic>\u2009\u00a0=\u00a0\u20090.480) or stage II<\/jats:styled-content> (P<\/jats:italic>\u2009\u00a0=\u00a0\u20090.917) tumors. Multivariate analysis revealed that preoperative anemia was an independent prognostic factor in TNM<\/jats:styled-content> stage III<\/jats:styled-content> (hazard ratio [HR<\/jats:styled-content>], 1.771; 95% CI<\/jats:styled-content>, 1.040\u20133.015; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.035). In a stage\u2010stratified analysis, preoperative anemia was still independently associated with OS<\/jats:styled-content> in TNM<\/jats:styled-content> stages III<\/jats:styled-content>a through III<\/jats:styled-content>c (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.075, and P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.012, respectively), though the association was only marginal in stage III<\/jats:styled-content>b. Of note, preoperative mild anemia had a similar prognostic value in TNM<\/jats:styled-content> stage III GC<\/jats:styled-content>. Furthermore, preoperative anemia was significantly associated with more perioperative transfusions, postoperative complications and several nutritional\u2010based indices, including the prognostic nutritional index (PNI<\/jats:styled-content>), preoperative weight loss and performance status (all P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05). Preoperative anemia, even mild anemia, was an important predictor of postoperative survival for TNM<\/jats:styled-content> stage III GC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/cam4.1309","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T06:45:42Z","timestamp":1516171542000},"page":"360-369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Impact of preoperative anemia on outcomes in patients undergoing curative resection for gastric cancer: a single\u2010institution retrospective analysis of 2163 Chinese patients"],"prefix":"10.1002","volume":"7","author":[{"given":"Xuechao","family":"Liu","sequence":"first","affiliation":[{"name":"Sun Yat\u2010sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"},{"name":"Department of Gastric Surgery Sun Yat\u2010sen University Cancer 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State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"},{"name":"Department of Gastric Surgery Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"},{"name":"Department of Gastric Surgery Sun Yat\u2010sen University Cancer Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfang","family":"Li","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"},{"name":"Department of Gastric Surgery Sun Yat\u2010sen University Cancer 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2321-5955","authenticated-orcid":false,"given":"Xiaowei","family":"Sun","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China"},{"name":"Department of Gastric Surgery Sun Yat\u2010sen University Cancer Center Guangzhou 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