{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:30:22Z","timestamp":1762324222674,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T00:00:00Z","timestamp":1519344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["17ck0106348 h0001"],"award-info":[{"award-number":["17ck0106348 h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diffuse large B\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>), which is the most prevalent disease subtype of non\u2010Hodgkin lymphoma, is highly heterogeneous in terms of cytogenetic and molecular features. This study retrospectively investigated the clinical impact of G\u2010banding\u2010defined chromosomal abnormality on treatment outcomes of <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> in the era of rituximab\u2010containing immunochemotherapy. Of 181 patients who were diagnosed with <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> and treated with R\u2010<jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content> or an R\u2010<jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content>\u2010like regimen between January 2006 and April 2014, metaphase spreads were evaluable for G\u2010banding in 120. In these 120 patients, 40 were found to harbor a single chromosomal aberration type; 63 showed chromosomal abnormality variations (<jats:styled-content style=\"fixed-case\">CAV<\/jats:styled-content>s), which are defined by the presence of different types of chromosomal abnormalities in G\u2010banding, including 19 with two <jats:styled-content style=\"fixed-case\">CAV<\/jats:styled-content>s and 44 with \u22653 <jats:styled-content style=\"fixed-case\">CAV<\/jats:styled-content>s; and 17 had normal karyotypes. No specific chromosomal break point or numerical abnormality was associated with overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) or progression\u2010free survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>), but the presence of \u22653 <jats:styled-content style=\"fixed-case\">CAV<\/jats:styled-content>s was significantly associated with inferior <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> rates (hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>): 2.222, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 1.056\u20134.677, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.031) and tended to be associated with shorter <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>: 1.796, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.965\u20133.344, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.061). In addition, \u22653 <jats:styled-content style=\"fixed-case\">CAV<\/jats:styled-content>s more frequently accumulated in high\u2010risk patients, as defined by several conventional prognostic indices, such as the revised International Prognostic Index. In conclusion, our results suggest that the emergence of more <jats:styled-content style=\"fixed-case\">CAV<\/jats:styled-content>s, especially \u22653, based on chromosomal instability underlies the development of high\u2010risk disease features and a poor prognosis in <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/cam4.1342","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T07:12:47Z","timestamp":1519369967000},"page":"655-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Chromosomal abnormality variation detected by G\u2010banding is associated with prognosis of diffuse large B\u2010cell lymphoma treated by R\u2010<scp>CHOP<\/scp>\u2010based therapy"],"prefix":"10.1002","volume":"7","author":[{"given":"Yoshimi","family":"Mizuno","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology Department of 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