{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:21:00Z","timestamp":1791346860207,"version":"4.3.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,5]],"date-time":"2013-10-05T00:00:00Z","timestamp":1380931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myelofibrosis (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>) is a clonal hematopoietic malignancy characterized by constitutional and localized symptoms, progressive splenomegaly, bone marrow fibrosis, and cytopenias. Although <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> is well studied, few studies exist regarding its symptomatic burden in routine clinical practice. This study aimed to characterize symptoms and other clinical features of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> among patients in the <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>nited <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tates. We conducted a retrospective medical record review of adult patients with an <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> diagnosis between 1 January 2005 and 31 March 2010, stratified by the presence of palpable splenomegaly. Eligible patients had 12\u00a0months or more of follow\u2010up after diagnosis (or after detection of splenomegaly, if present) unless death occurred. Demographic and clinical characteristics, <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>\u2010related symptoms, and treatments were reported by treating physicians. We report on 180 <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> patients: 102 with splenomegaly, 78 without. Median age was 66\u00a0years, 63% were male, and 82% had intermediate\u20102 or high\u2010risk <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternational <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rognostic <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>coring <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ystem). Fatigue was reported by ~85% of patients; weight loss, night sweats, and fever (any grade) were each reported by 50% or more of patients. Generalized abdominal pain, left subcostal pain, and early satiety occurred more frequently among patients with splenomegaly. Multiple symptoms were reported by 95% of patients. Common comorbidities were hypertension, diabetes, and chronic pulmonary disease. Symptoms are common in <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> patients, regardless of the presence of palpable splenomegaly. Careful assessment of symptom burden is an important aspect of the clinical evaluation of patients with <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/cam4.136","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:54:22Z","timestamp":1381542862000},"page":"889-898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Symptom burden and splenomegaly in patients with myelofibrosis in the <scp>U<\/scp>nited <scp>S<\/scp>tates: a retrospective medical record review"],"prefix":"10.1002","volume":"2","author":[{"given":"Debanjali","family":"Mitra","sequence":"first","affiliation":[{"name":"RTI Health Solutions Research Triangle Park North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Kaye","sequence":"additional","affiliation":[{"name":"RTI Health Solutions Research Triangle Park North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance T.","family":"Piecoro","sequence":"additional","affiliation":[{"name":"Incyte Corporation Wilmington Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Brown","sequence":"additional","affiliation":[{"name":"Incyte Corporation Wilmington Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Reith","sequence":"additional","affiliation":[{"name":"Incyte Corporation Wilmington Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq I.","family":"Mughal","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Sarlis","sequence":"additional","affiliation":[{"name":"Incyte Corporation Wilmington Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2011.1.222"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404914"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004273421706"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.moh.0000208469.48614.2e"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22365"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-170449"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-195974"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3128"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1069(199711)15:4<173::AID-HON610>3.0.CO;2-K"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199905)61:1<10::AID-AJH3>3.0.CO;2-I"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110557"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110556"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V120.21.800.800","article-title":"Long\u2010term outcome of ruxolitinib treatment in patients with myelofibrosis: durable reductions in spleen volume, improvements in quality of life, and overall survival advantage in COMFORT\u2010I","volume":"120","author":"Verstovsek S.","year":"2012","journal-title":"Blood"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V120.21.801.801","article-title":"Long\u2010term safety, efficacy, and survival findings from COMFORT\u2010II, a phase 3 study comparing ruxolitinib with best available therapy (BAT) for the treatment of myelofibrosis (MF)","volume":"120","author":"Cervantes F.","year":"2012","journal-title":"Blood"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-328955"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22630"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-209262"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-083501"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-245837"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.2446"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2009.0543"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","DOI":"10.1200\/jco.2011.29.15_suppl.6610","article-title":"Symptomatic burden in myelofibrosis (MF): prospective international assessment in 128 MF patients","volume":"29","author":"Scherber R. M.","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002028"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","DOI":"10.1200\/jco.2012.30.15_suppl.6626","article-title":"Health\u2010related quality of life (HRQoL) and symptom burden in patients (Pts) with myelofibrosis (MF) in the COMFORT\u2010II study","volume":"30","author":"Kiladjian J. J.","year":"2012","journal-title":"J. Clin. 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