{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:18:37Z","timestamp":1778537917130,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Abstract<\/jats:title>Regional hyperthermia is considered to enhance the antitumor effects of chemotherapy and radiotherapy. In this study, we confirmed the efficacy of concomitant radiotherapy, hyperthermia, and chemotherapy (RHC<\/jats:styled-content>) for neoadjuvant treatment of malignant soft tissue sarcoma (STS<\/jats:styled-content>). From 1994 to 2013, we performed RHC<\/jats:styled-content> in 150 patients. This study was limited to 60 patients using the following exclusion criteria: salvage for recurrence or unplanned excision, trunk location, metastasis at initiation, non\u2010STS<\/jats:styled-content>, and no definitive surgery. As a control group, we collected data from 11,031 patients in the Bone and Soft Tissue Tumor Registry in Japan (BSTT<\/jats:styled-content>). We performed multivariate logistic regression analysis, and propensity scores were created for comparisons between groups. The primary outcome of this study was to compare oncologic outcomes (5\u2010year local control rate [LC<\/jats:styled-content>] and overall survival rate [OS<\/jats:styled-content>]). In the RHC<\/jats:styled-content> group, two local recurrences (3.3%) occurred, and no patients underwent amputation. Margins of definitive surgery were not identical between groups [wide margins (60.0% vs. 85.3%), marginal margins (28.3% vs. 10.5%), and intralesional margins (7.4% vs. 4.2%), RHC<\/jats:styled-content> and BSTT<\/jats:styled-content> groups, respectively, P<\/jats:italic>\u00a0<\u00a00.001]. After adjustment, the difference in OS<\/jats:styled-content> was not significant between groups (HR<\/jats:styled-content>\u00a0=\u00a01.26, P<\/jats:italic>\u00a0=\u00a00.532); however, a statistically significant difference in LC<\/jats:styled-content> was observed (HR<\/jats:styled-content>\u00a0=\u00a04.82, P<\/jats:italic>\u00a0=\u00a00.037). RHC<\/jats:styled-content> resulted in a high LC<\/jats:styled-content> at 5\u00a0years compared to the BSTT<\/jats:styled-content> group, and amputation was averted in the RHC<\/jats:styled-content> group, despite the wider margins in the BSTT<\/jats:styled-content> group. This indicates that less invasive surgery might be achieved with effective neoadjuvant therapy.<\/jats:p>","DOI":"10.1002\/cam4.1366","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T08:46:37Z","timestamp":1519634797000},"page":"1560-1571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical outcomes of radio\u2010hyperthermo\u2010chemotherapy for soft tissue sarcoma compared to a soft tissue sarcoma registry in Japan: a retrospective matched\u2010pair cohort study"],"prefix":"10.1002","volume":"7","author":[{"given":"Hisaki","family":"Aiba","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Nagoya City University Graduate School of Medical Sciences Nagoya Aichi Japan"},{"name":"Department of Orthopedic Surgery Graduate School of Medical Sciences Kanazawa University Kanazawa Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5513-2981","authenticated-orcid":false,"given":"Satoshi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Nagoya City University Graduate School of Medical Sciences Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Nagoya City University Graduate School of Medical Sciences Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Graduate School of Medical Sciences Kanazawa University Kanazawa Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Nagoya City University Graduate School of Medical Sciences Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Graduate School of Medical Sciences Kanazawa University Kanazawa Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Graduate School of Medical Sciences Kanazawa University Kanazawa Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Graduate School of Medical Sciences Kanazawa University Kanazawa Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5962-8287","authenticated-orcid":false,"given":"Shinji","family":"Miwa","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Nagoya City University Graduate School of Medical Sciences Nagoya Aichi Japan"},{"name":"Department of Orthopedic Surgery Graduate School of Medical Sciences Kanazawa University Kanazawa Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Oncology National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Innovative Clinical Research Center Kanazawa University Kanazawa Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Graduate School of Medical Sciences Kanazawa University Kanazawa Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanobu","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Nagoya City University Graduate School of Medical Sciences Nagoya Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.31.5.271"},{"key":"e_1_2_7_3_1","volume-title":"Enzinger and Weiss's soft tissue tumors","author":"Weiss S. 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To Kagaku Ryoho"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.1366","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.1366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T05:49:39Z","timestamp":1723096179000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.1366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,26]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1002\/cam4.1366"],"URL":"https:\/\/doi.org\/10.1002\/cam4.1366","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,26]]},"assertion":[{"value":"2017-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}