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We analyzed the relationship between statins and risk of <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> using data from the Women's Health Initiative (<jats:styled-content style=\"fixed-case\">WHI<\/jats:styled-content>). The study population included 161,563 postmenopausal women ages 50\u201379\u00a0years from which 712 cases of <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> were diagnosed after 10.8\u00a0years of follow\u2010up. Information on statin use and other risk factors was collected by self\u2010 and interviewer\u2010administered questionnaires. Multivariable\u2010adjusted <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> and 95% CI evaluating the relationship between statin use at baseline, as well as in a time\u2010dependent manner and risk of <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>, were computed from Cox proportional hazards analyses. A separate analysis was performed for individual <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> subtypes: diffuse large B\u2010Cell lymphoma (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>) (<jats:italic>n<\/jats:italic>\u00a0=\u00a0228), follicular lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a0169), and small lymphocytic lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a074). All statistical tests were two\u2010sided. There was no significant association between use of statins at baseline and risk of <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.85, 95% C.I. 0.67\u20131.08). However, in the multivariable\u2010adjusted time\u2010dependent models, statin use was associated with a borderline lower risk of <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.81, 95% C.I. 0.66\u20131.00). Considering subtypes of <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>, statin use was associated with a lower risk of <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.62, 95% C.I. 0.42\u20130.91). This effect was driven by lipophilic statins (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.62, 95% C.I. 0.40\u20130.96). In the <jats:styled-content style=\"fixed-case\">WHI<\/jats:styled-content>, statins were associated with a lower overall risk of <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>, particularly attributable to lipophilic statins. These results may have impact on primary or secondary prevention of <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>, particularly <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/cam4.1368","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T13:30:44Z","timestamp":1522675844000},"page":"2121-2130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["An analysis of the effect of statins on the risk of Non\u2010Hodgkin's Lymphoma in the Women\u2019s Health Initiative cohort"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-7284","authenticated-orcid":false,"given":"Pinkal","family":"Desai","sequence":"first","affiliation":[{"name":"Weill Cornell Medical College  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Iowa College of Public Health  Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew L.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara V.","family":"Howard","sequence":"additional","affiliation":[{"name":"MedStar Health Research Institute and Georgetown\/Howard Universities Center for Clinical and Translational Science  Washington District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Ray","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Safford","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa W.","family":"Martin","sequence":"additional","affiliation":[{"name":"George Washington University  Washington District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Schlecht","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine  Bronx New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simin","family":"Liu","sequence":"additional","affiliation":[{"name":"Brown University School of Public Health  Providence Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Iowa College of Public Health  Iowa City Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Jay","sequence":"additional","affiliation":[{"name":"St John Providence Hospital  Warren Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JoAnn E.","family":"Manson","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3237-6761","authenticated-orcid":false,"given":"Michael S.","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Oncology Karmanos Cancer Institute Wayne State University  Detroit Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,2]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"National Center for Health Statistics.Health United States 2010: with special feature on death and dying 2011. 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