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More specifically, tonsillar squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content>) and base of tongue squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">BOTSCC<\/jats:styled-content>) have much higher <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> prevalence compared to other <jats:styled-content style=\"fixed-case\">OPSCC<\/jats:styled-content>. Moreover, patients with <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> positive (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>+) <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BOTSCC<\/jats:styled-content> have a better prognosis as compared to patients with <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> negative (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2212) corresponding tumors, while the prognostic role of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> in other <jats:styled-content style=\"fixed-case\">OPSCC<\/jats:styled-content> is unclear. Furthermore, in a recent report from Denmark, <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> was further subclassified into specified <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">STSCC<\/jats:styled-content>) and nonspecified <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">NSTSCC<\/jats:styled-content>), with <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> significantly more prevalent in <jats:styled-content style=\"fixed-case\">STSCC<\/jats:styled-content>. In this study, the histopathological influence of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> prevalence and survival in <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> was analyzed in a <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> cohort with known <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> status, of patients diagnosed 1970\u20132002 in Stockholm. In total, 139 <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> biopsies with both tumor and adjacent normal tissue were separated into <jats:styled-content style=\"fixed-case\">STSCC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NSTSCC<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> was significantly more commonly found in <jats:styled-content style=\"fixed-case\">STSCC<\/jats:styled-content> than in <jats:styled-content style=\"fixed-case\">NSTSCC<\/jats:styled-content>. Patients with <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>+ <jats:styled-content style=\"fixed-case\">STSCC<\/jats:styled-content> had a better disease\u2010specific and overall survival as compared to patients with <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>+ <jats:styled-content style=\"fixed-case\">NSTSCC<\/jats:styled-content>, but no survival differences were observed in patients with <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2212 <jats:styled-content style=\"fixed-case\">STSCC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NSTCC<\/jats:styled-content>. These findings confirm previous reports and suggest that <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> subsite may also be of relevance for clinical outcome and should be further followed up in future studies.<\/jats:p>","DOI":"10.1002\/cam4.1400","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T04:19:52Z","timestamp":1521865192000},"page":"1717-1722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma"],"prefix":"10.1002","volume":"7","author":[{"given":"Linnea","family":"Haeggblom","sequence":"first","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  171 76 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tove","family":"Attoff","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  171 76 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalle","family":"Hammarstedt\u2010Nordenvall","sequence":"additional","affiliation":[{"name":"Department of Oto\u2010Rhino\u2010Laryngology, Head and Neck Surgery Karolinska University Hospital  171 76 Stockholm Sweden"},{"name":"Department of Clinical Science, Intervention and Technology Karolinska Institutet  171 76 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4602-4297","authenticated-orcid":false,"given":"Anders","family":"N\u00e4sman","sequence":"additional","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  171 76 Stockholm Sweden"},{"name":"Department of Clinical Pathology Karolinska University Hospital  171 76 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,23]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"IARC.A review of human carcinogens. monographs on the evaluation of carcinogenic risks to humans 2009; 100B."},{"key":"e_1_2_7_3_1","unstructured":"Amin M. 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