{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:52:13Z","timestamp":1791229933817,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T00:00:00Z","timestamp":1520899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang provincial medical platform 2015 specialists class B","award":["2015 RCB016"],"award-info":[{"award-number":["2015 RCB016"]}]},{"name":"Zhejiang province key science and technology innovation team","award":["2013TD13"],"award-info":[{"award-number":["2013TD13"]}]},{"name":"Zhejiang Natural Science Foundation of China","award":["LY18H160019"],"award-info":[{"award-number":["LY18H160019"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>With an increasing trend of patients with young\u2010onset colorectal cancer (CRC), risks of second primary cancers (SPCs) among them become a concerning issue. We aimed to define the detailed risk and site\u2010distributed patterns of SPCs in young CRC individuals (age \u226450). A population\u2010based cohort were identified from the Surveillance, Epidemiology, and End Results database between 1973 and 2013. Standardized incidence ratios (SIRs) and absolute excess risk (AER) were calculated to assess the risk for SPCs compared with the general population. A total of 44,106 patients, including 3245 (7.4%) the young and 40,861 (92.6%) the old, developed 50,679 secondary malignancies subsequently. With increased age, the risk of secondary cancers gradually decreased. A significant 44% excess risk of SPCs was observed in the young (SIR\u00a0=\u00a01.44, AER\u00a0=\u00a034.23), while a slightly increased risk was noted in the old (SIR\u00a0=\u00a01.02, AER\u00a0=\u00a04.29). For young survivors, the small intestine (SIR\u00a0=\u00a08.49), bile ducts (SIR\u00a0=\u00a03.77), corpus, and uterus (SIR\u00a0=\u00a02.45) were the most common sites of SPCs. Significantly, excess SIRs in the young were persisted regardless of other factors. For the young, secondary cancer\u2010related deaths were responsible for 51.2% of overall deaths and secondary stomach, liver and bile, pancreas cancers were top three causes. An excessive risk of SPCs existed in young CRC survivors, and this trend was consistent among different subgroups. We hope our findings may inform future targeted screening strategies among young\u2010onset CRC survivors.<\/jats:p>","DOI":"10.1002\/cam4.1437","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T06:56:43Z","timestamp":1521097003000},"page":"1201-1210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Excessive risk of second primary cancers in young\u2010onset colorectal cancer survivors"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1586-2266","authenticated-orcid":false,"given":"Xingkang","family":"He","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Sir Run Run Shaw Hospital Zhejiang University Medical School  Hangzhou China"},{"name":"Institute of Gastroenterology Zhejiang University (IGZJU)  Hangzhou China"},{"name":"Department of Microbiology Tumor and Cell Biology Karolinska Institute  171 77 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenrui","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu'e","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sir Run Run Shaw Hospital Zhejiang University Medical School  Hangzhou China"},{"name":"Institute of Gastroenterology Zhejiang University (IGZJU)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sir Run Run Shaw Hospital Zhejiang University Medical School  Hangzhou China"},{"name":"Institute of Gastroenterology Zhejiang University (IGZJU)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sir Run Run Shaw Hospital Zhejiang University Medical School  Hangzhou China"},{"name":"Institute of Gastroenterology Zhejiang University (IGZJU)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leimin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sir Run Run Shaw Hospital Zhejiang University Medical School  Hangzhou China"},{"name":"Institute of Gastroenterology Zhejiang University (IGZJU)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24760"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw322"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21395"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21349"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0067"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28769"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605616"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30164"},{"key":"e_1_2_7_11_1","first-page":"793","article-title":"Second primary cancers after sporadic and familial colorectal cancer","volume":"10","author":"Hemminki K.","year":"2001","journal-title":"Cancer Epidemiol. 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