{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:20:33Z","timestamp":1778113233221,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Public Welfare Foundation of Liaoning Province","award":["2015005002"],"award-info":[{"award-number":["2015005002"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>As an indispensable factor in DNA<\/jats:styled-content> damage recognition step of nucleotide excision repair, XPA<\/jats:styled-content> interacts with a series of proteins to initiate repair process. The expression characteristics of XPA<\/jats:styled-content> in colorectal cancer (CRC<\/jats:styled-content>) and its influence on CRC<\/jats:styled-content> prognosis remain elusive. Tissue specimens of CRC<\/jats:styled-content> and nontumor adjacent tissues from 283 patients were collected. XPA<\/jats:styled-content> protein expressions were detected by immunohistochemistry staining. Nonparametric test was used to investigate the difference of XPA<\/jats:styled-content> expression between CRC<\/jats:styled-content> and nontumor adjacent tissues, as well as the correlation between XPA<\/jats:styled-content> expression and clinicopathological parameters of CRC<\/jats:styled-content>. Univariate and multivariate Cox proportional hazards models were applied to estimate the relationship between XPA<\/jats:styled-content> expression and CRC<\/jats:styled-content> prognosis. Meanwhile, we analyzed TCGA<\/jats:styled-content> data to investigate the relation between XPA mRNA<\/jats:styled-content> expression and survival of CRC<\/jats:styled-content>. XPA<\/jats:styled-content> protein expression was significantly decreased in CRC<\/jats:styled-content> tissues compared with nontumor adjacent tissues (P<\/jats:italic>\u00a0=\u00a00.001). Subgroup analysis indicated consistently significant down\u2010regulation of XPA<\/jats:styled-content> in CRC<\/jats:styled-content> tissues in age\u00a0>\u00a060 (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.026), age\u00a0\u2264\u00a060 (P<\/jats:italic>\u00a0=\u00a00.008), colon cancer (P<\/jats:italic>\u00a0=\u00a00.009), and rectal cancer (P<\/jats:italic>\u00a0=\u00a00.015) patients and males (P<\/jats:italic>\u00a0=\u00a00.004). For clinicopathological parameters, CRC<\/jats:styled-content> patients with drinking habits revealed XPA<\/jats:styled-content> overexpression than nondrinkers (P<\/jats:italic>\u00a0=\u00a00.032). For prognosis, CRC<\/jats:styled-content> patients with high XPA<\/jats:styled-content> protein expression had longer overall survival (OS<\/jats:styled-content>) (HR<\/jats:styled-content>\u00a0=\u00a00.62, 95%CI<\/jats:styled-content>: 0.39\u20130.97, P<\/jats:italic>\u00a0=\u00a00.037). Stratified analysis suggested a better prognosis in relation to high XPA<\/jats:styled-content> protein expression in patients over 60\u00a0years (adjusted HR<\/jats:styled-content>\u00a0=\u00a00.48, P<\/jats:italic>\u00a0=\u00a00.021), with rectal cancer (HR<\/jats:styled-content>\u00a0=\u00a00.56, P<\/jats:italic>\u00a0=\u00a00.037), without distant metastasis (HR<\/jats:styled-content>\u00a0=\u00a00.58, P<\/jats:italic>\u00a0=\u00a00.033), without tumor deposits (HR<\/jats:styled-content>\u00a0=\u00a00.40, P<\/jats:italic>\u00a0=\u00a00.006; adjusted HR<\/jats:styled-content>\u00a0=\u00a00.44, P<\/jats:italic>\u00a0=\u00a00.028), and with tumor diameter over 4\u00a0cm (HR<\/jats:styled-content>\u00a0=\u00a00.49, P<\/jats:italic>\u00a0=\u00a00.023). DNA<\/jats:styled-content> repair protein XPA<\/jats:styled-content> is significantly decreased in colorectal cancer tissues than in adjacent nontumor tissues. High expression of XPA<\/jats:styled-content> protein showed significant relationship with better survival of CRC<\/jats:styled-content>, especially rectal cancer. XPA<\/jats:styled-content> might be a novel biomarker but might not be an independent factor to predict prognosis of CRC<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1002\/cam4.1480","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T00:10:46Z","timestamp":1524183046000},"page":"2339-2349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["DNA<\/scp> repair protein XPA<\/scp> is differentially expressed in colorectal cancer and predicts better prognosis"],"prefix":"10.1002","volume":"7","author":[{"given":"Xue","family":"Feng","sequence":"first","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery The First Hospital of China Medical University Shenyang 110001 China"},{"name":"Liaoning Provincial Education Department Key Laboratory of Cancer Etiology and Prevention China Medical University Shenyang 110001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery The First Hospital of China Medical University Shenyang 110001 China"},{"name":"Liaoning Provincial Education Department Key Laboratory of Cancer Etiology and Prevention China Medical University Shenyang 110001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehua","family":"Gong","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery The First Hospital of China Medical University Shenyang 110001 China"},{"name":"Liaoning Provincial Education Department Key Laboratory of Cancer Etiology and Prevention China Medical University Shenyang 110001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaihua","family":"Gou","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery The First Hospital of China Medical University Shenyang 110001 China"},{"name":"Liaoning Provincial Education Department Key Laboratory of Cancer Etiology and Prevention China Medical University Shenyang 110001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaiwei","family":"Yang","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery The First Hospital of China Medical University Shenyang 110001 China"},{"name":"Liaoning Provincial Education Department Key Laboratory of Cancer Etiology and Prevention China Medical University Shenyang 110001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7089-2062","authenticated-orcid":false,"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery The First Hospital of China Medical University Shenyang 110001 China"},{"name":"Liaoning Provincial Education Department Key Laboratory of Cancer Etiology and Prevention China Medical University Shenyang 110001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6463-019X","authenticated-orcid":false,"given":"Chengzhong","family":"Xing","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery The First Hospital of China Medical University Shenyang 110001 China"},{"name":"Liaoning Provincial Education Department Key Laboratory of Cancer Etiology and Prevention China Medical University Shenyang 110001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,19]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"247","article-title":"DNA repair pathways and their involvement in human diseases","volume":"107","author":"Sandovici I.","year":"2002","journal-title":"Rev. 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