{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:32:46Z","timestamp":1743726766553,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hunan Department of Science and Technology Foundation, China","award":["2016SK2007"],"award-info":[{"award-number":["2016SK2007"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to clarify the prognostic role of paranasal sinus invasion in advanced <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> patients. Data of patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0295) with advanced <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> (T3\/T4N0\u20103 M0) treated with intensity\u2010modulated radiation therapy were retrospectively analyzed. Staging was according to the <jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">UICC<\/jats:styled-content> eighth edition staging system. Overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>), local recurrence\u2010free survival (<jats:styled-content style=\"fixed-case\">LRFS<\/jats:styled-content>), distant metastasis\u2010free survival (<jats:styled-content style=\"fixed-case\">DMFS<\/jats:styled-content>), and disease\u2010free survival (<jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content>) were calculated, and differences were compared between patients with and without paranasal sinus invasion. Multivariate analysis was used to identify the independent predictors of different survival parameters. Paranasal sinus invasion was present in 126 of 295 (42.7%) patients. Sphenoid, ethmoid, maxillary, and frontal sinus involvements were present in 123 of 295 (41.7%), 95 of 295 (32.2%), 45 of 295 (15.3%), and 0 of 295 (0%), respectively. All survival parameters were significantly better in patients without paranasal sinus invasion. When paranasal sinus invasion was reclassified as T4 instead of T3, all survival rates, other than <jats:styled-content style=\"fixed-case\">LRFS<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.156), were significantly better in the new T3 patients, and differences in all survival parameters remained nonsignificant between T3 with paranasal sinus invasion and T4 without paranasal sinus invasion patients (all <jats:italic>P\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.05). In multivariate analysis, paranasal sinus invasion was found to be an independent negative prognostic factor for <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> DFS<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">DMFS<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.016, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.004, and <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.006, respectively), but not for <jats:styled-content style=\"fixed-case\">LRFS<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.068). Paranasal sinus invasion has prognostic value in advanced <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content>. It may be reasonable to classify paranasal sinus invasion as T4 stage.<\/jats:p>","DOI":"10.1002\/cam4.1506","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T04:34:02Z","timestamp":1525235642000},"page":"2826-2836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of paranasal sinus invasion on advanced nasopharyngeal carcinoma treated with intensity\u2010modulated radiation therapy: the validity of advanced T stage of <scp>AJCC<\/scp>\/<scp>UICC<\/scp> eighth edition staging system"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0711-0854","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Oncology Xiangya Hospital Central South University  No. 87, Xiangya Road Changsha Hunan Province 410008 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Oncology Xiangya Hospital Central South University  No. 87, Xiangya Road Changsha Hunan Province 410008 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oncology Xiangya Hospital Central South University  No. 87, Xiangya Road Changsha Hunan Province 410008 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingjun","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Oncology Xiangya Hospital Central South University  No. 87, Xiangya Road Changsha Hunan Province 410008 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanzhan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology Xiangya Hospital Central South University  No. 87, Xiangya Road Changsha Hunan Province 410008 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Oncology Xiangya Hospital Central South University  No. 87, Xiangya Road Changsha Hunan Province 410008 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dengming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Oncology Xiangya Hospital Central South University  No. 87, Xiangya Road Changsha Hunan Province 410008 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangfang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Oncology Xiangya Hospital Central South University  No. 87, Xiangya Road Changsha Hunan Province 410008 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"International Agency for Research on Cancer.GLOBOCAN 2012. 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