{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T14:06:35Z","timestamp":1775138795580,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T00:00:00Z","timestamp":1525651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703023"],"award-info":[{"award-number":["81703023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There are conflicting reports about whether radiotherapy or surgery is optimal for early\u2010stage laryngeal squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content>), although both have recently been recommended. Patients with T1\u20102N0M0 <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content> in the population\u2010based <jats:styled-content style=\"fixed-case\">SEER<\/jats:styled-content> database who underwent radiotherapy or surgery were reviewed. Propensity score matching was used to eliminate the baseline variations. After matching, 1913 pairs of patients were included. Overall, patients who received radiotherapy had worse cancer\u2010specific survival than patients with surgery. After stratification, the survival in patients who received radiotherapy was worse with respect to the following characteristics: \u226460\u00a0years of age; T1a glottis cancer; well\u2010differentiated tumors; and with married status. In other patients, survival outcomes were similar in patients who received radiotherapy and underwent surgery. Our results indicate that radiotherapy is not preferable in early\u2010stage <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content> patients who are \u226460\u00a0years of age, have T1a glottis cancer or well\u2010differentiated tumors, or are married. In other patients, both radiotherapy and surgery are comparable. However, our results cannot be a reference before controlled, prospective trials are performed.<\/jats:p>","DOI":"10.1002\/cam4.1525","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T13:48:49Z","timestamp":1525700929000},"page":"2837-2847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Radiotherapy vs surgery for T1\u20102N0M0 laryngeal squamous cell carcinoma: A population\u2010based and propensity score matching study"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8745-9276","authenticated-orcid":false,"given":"Cheng","family":"Zhan","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinmao","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Eye &amp; ENT Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0697-7838","authenticated-orcid":false,"given":"Li","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Eye &amp; ENT Hospital Fudan University  Shanghai 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