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Most patients received radiotherapy during the course of disease. However, radioresistance generally occurs in the majority of these patients, leading to poor curative effect, and the underlying mechanism remains unclear. In the present study, miR\u201018a\u20105p expression was downregulated in irradiated lung cancer cells. Overexpression of miR\u201018a\u20105p increased the radiosensitivity of lung cancer cells and inhibited the growth of A549 xenografts after radiation exposure. Dual luciferase report system and miR\u201018a\u20105p overexpression identified ataxia telangiectasia mutated (<jats:styled-content style=\"fixed-case\">ATM<\/jats:styled-content>) and hypoxia inducible factor 1 alpha (<jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\u20101\u03b1) as the targets of miR\u201018a\u20105p. The <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and protein expressions of <jats:styled-content style=\"fixed-case\">ATM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\u20101\u03b1 were dramatically downregulated by miR\u201018a\u20105p in vitro and in vivo. Clinically, plasma miR\u201018a\u20105p expression was significantly higher in radiosensitive than in radioresistant group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The cutoff value of miR\u201018a\u20105p &gt;2.28 was obtained from receiver operating characteristic (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) curve. The objective response rate (<jats:styled-content style=\"fixed-case\">ORR<\/jats:styled-content>) was significantly higher in miR\u201018a\u20105p\u2010high group than in miR\u201018a\u20105p\u2010low group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). A tendency demonstrated that the median local progression\u2010free survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>) from radiotherapy was longer in miR\u201018a\u20105p\u2010high than in miR\u201018a\u20105p\u2010low group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.082). The median overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) from radiotherapy was numerically longer in miR\u201018a\u20105p\u2010high than in miR\u201018a\u20105p\u2010low group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.281). The sensitivity and specificity of plasma miR\u201018a\u20105p to predict radiosensitivity was 87% and 95%, respectively. Collectively, these results indicate that miR\u201018a\u20105p increases the radiosensitivity in lung cancer cells and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>133<jats:sup>+<\/jats:sup> stem\u2010like cells via downregulating <jats:styled-content style=\"fixed-case\">ATM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HIF<\/jats:styled-content>\u20101\u03b1 expressions. Plasma miR\u201018a\u20105p would be an available indicator of radiosensitivity in lung cancer patients.<\/jats:p>","DOI":"10.1002\/cam4.1527","type":"journal-article","created":{"date-parts":[[2018,6,3]],"date-time":"2018-06-03T04:10:56Z","timestamp":1527999056000},"page":"3834-3847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Radiosensitizing effects of miR\u201018a\u20105p on lung cancer stem\u2010like cells via downregulating both <scp>ATM<\/scp> and <scp>HIF<\/scp>\u20101\u03b1"],"prefix":"10.1002","volume":"7","author":[{"given":"Xu","family":"Chen","sequence":"first","affiliation":[{"name":"Cancer Institute, Xinqiao Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gerontology Chongqing General Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhi","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Institute, Xinqiao Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Xu","sequence":"additional","affiliation":[{"name":"Oncology Department Leshan People\u2019s Hospital  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Institute, Xinqiao Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Niu","sequence":"additional","affiliation":[{"name":"Cancer Institute, Xinqiao Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Kong","sequence":"additional","affiliation":[{"name":"Cancer Institute, Xinqiao Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoyang","family":"Gu","sequence":"additional","affiliation":[{"name":"Cancer Institute, Xinqiao Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Xu","sequence":"additional","affiliation":[{"name":"Cancer Institute, Xinqiao Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengtang","family":"Chen","sequence":"additional","affiliation":[{"name":"Cancer Institute, Xinqiao Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2991-571X","authenticated-orcid":false,"given":"Jianguo","family":"Sun","sequence":"additional","affiliation":[{"name":"Cancer Institute, Xinqiao Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62038-9"},{"issue":"4","key":"e_1_2_6_3_1","first-page":"S389","article-title":"Treatment of non\u2010small cell lung cancer (NSCLC)","volume":"5","author":"Zarogoulidis K","year":"2013","journal-title":"J Thorac Dis"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1278-3218(97)83533-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbs.2015.11.012"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.02.002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.01.012"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07733"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.03.024"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-11-304"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076994"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17010093"},{"key":"e_1_2_6_13_1","unstructured":"The microRNA Database.https:\/\/www.mirbase.org. 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