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This prospective, multicenter, noninterventional study analyzed how efficacy and safety data from randomized controlled trials translate into clinical practice in Germany. Both treatment\u2010na\u00efve and relapsed\/refractory patients with <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>, who responded to rituximab\u2010containing induction and were scheduled for rituximab maintenance, were observed for 24\u00a0months. Effectiveness was measured by response and Kaplan\u2010Meier survival analysis. In addition, treatment patterns of induction and maintenance, as well as adverse events, were documented. The evaluable study population consisted of 310 first\u2010line patients and 173 relapsed\/refractory patients, including 116 patients with initial Ann\u2010Arbor stage I\/<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and 20 patients with <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> grade 3B. Regarding first\u2010line induction, a shift from R\u2010<jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content> (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) to R\u2010bendamustine was observed over time, as well as a decline in radiotherapy. 2\u2010year progression\u2010free survival rates were 88.3% (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 84.0\u201092.6) for first\u2010line patients and 76.0% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 68.8\u201083.3) for relapsed\/refractory patients. Conversion from partial to complete remission (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CR<\/jats:styled-content>) occurred in 53.4% of analyzed first\u2010line patients with <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>, resulting in 69.4% <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>s at study end (relapsed\/refractory: conversion in 42.9%, final <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>s 57.9%). Safety results were consistent with the known safety profile of rituximab in this setting. Both treatment\u2010na\u00efve and relapsed\/refractory patients with <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> show favorable 2\u2010year <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> rates and improvements in the remission status with postinduction rituximab monotherapy as maintenance and consolidation therapy.<\/jats:p>","DOI":"10.1002\/cam4.1549","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T09:30:46Z","timestamp":1526376646000},"page":"2903-2912","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rituximab maintenance therapy of follicular lymphoma in clinical practice"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4034-9472","authenticated-orcid":false,"given":"Ulrich","family":"D\u00fchrsen","sequence":"first","affiliation":[{"name":"Department of Hematology University Hospital Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Broszeit\u2010Luft","sequence":"additional","affiliation":[{"name":"Oncological Practice  Lehrte Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Dieing","sequence":"additional","affiliation":[{"name":"Vivantes Medical Care Center at Urban  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"L\u00fcck","sequence":"additional","affiliation":[{"name":"Center for Oncology and Urology at Rostock  Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Porowski","sequence":"additional","affiliation":[{"name":"Oncological Practice  Heilbronn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Reiser","sequence":"additional","affiliation":[{"name":"Practice for Internal Oncology and Hematology  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Schwinger","sequence":"additional","affiliation":[{"name":"Oncological Practice  Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Klawitter","sequence":"additional","affiliation":[{"name":"Roche Pharma AG  Grenzach\u2010Wyhlen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Krumm","sequence":"additional","affiliation":[{"name":"Roche Pharma AG  Grenzach\u2010Wyhlen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Jentsch\u2010Ullrich","sequence":"additional","affiliation":[{"name":"Practice for Hematology and Oncology  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.8.2780"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2508"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08942.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw400"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S69145"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0016"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61763-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3175"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.4786"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.1561"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62175-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.5827"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-016725"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V122.21.509.509"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-021113"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.01.021"},{"key":"e_1_2_7_19_1","unstructured":"National Comprehensive Cancer Network.NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae). 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