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Since first report of the breast cancer (<jats:styled-content style=\"fixed-case\">BCA<\/jats:styled-content>) promoting function by S1P production (through the function of sphingosine kinases) and S1P\/S1<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> signaling, their antagonists have never been successfully progress to clinics after three decades. Taking advantage of bioinformatics linking to gene expression to disease prognosis, we examined the impact of associated genes in <jats:styled-content style=\"fixed-case\">BCA<\/jats:styled-content> patients. We found high gene expressions involved in S1P anabolism suppressed disease progression of patients who are basal cell type <jats:styled-content style=\"fixed-case\">BCA<\/jats:styled-content> or receiving adjuvant therapy. In addition, S1<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>s expression also suppressed disease progress of multiple categories of <jats:styled-content style=\"fixed-case\">BCA<\/jats:styled-content> patient progression. This result is contradictory to tumor promoter role of S1P\/S1<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>s which revealed in the literature. Further examination by directly adding S1P in <jats:styled-content style=\"fixed-case\">BCA<\/jats:styled-content> cells found a cell growth suppression function, which act via the expression of S1<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>1. In conclusion, our study is the first evidence claiming a survival benefit function of S1P\/S1<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> signaling in <jats:styled-content style=\"fixed-case\">BCA<\/jats:styled-content> patients, which might explain the obstacle of relative antagonist apply in clinics.<\/jats:p>","DOI":"10.1002\/cam4.1609","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T10:29:23Z","timestamp":1529490563000},"page":"3743-3754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Survival benefit of sphingosin\u20101\u2010phosphate and receptors expressions in breast cancer patients"],"prefix":"10.1002","volume":"7","author":[{"given":"Fu\u2010Ju","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Medicine Graduate Institution of Clinical Medical Science Graduate Institute of Biomedical Sciences School of Medicine China 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