{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:30:52Z","timestamp":1761611452745,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T00:00:00Z","timestamp":1530489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772987"],"award-info":[{"award-number":["81772987"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gastric tumorigenesis is a multistep process initiated by chronic superficial gastritis (SG), followed by atrophic gastritis (AG), then intestinal metaplasia (IM), and finally by dysplasia and adenocarcinoma according to the Correa model. Pepsinogen C (PGC) decreases gradually during progression of cancer, which makes PGC an ideal negative marker for GC. To explore the correlation between PGC and other positive tumor markers in different gastric diseases, we observed the expression of PGC, MG7\u2010Ag, MMP9, NM23, Ki\u201067, and E\u2010cadherin by immunohistochemistry, quantitative RT\u2010PCR, and immunoblot analysis. Our results showed that in SG, PGC was highly expressed while malignant phenotype markers were rarely expressed. In contrast with SG, malignant phenotype markers were highly expressed while the positive rate of PGC reached only 1.44% in GC. So there was no coexpression of PGC and malignant phenotype markers in SG or GC tissues. Only in the AG group, which is well\u2010known to be gastric precancerous disease, coexpression of PGC and malignant phenotype markers was detected. Our results suggested that the expression of PGC in AG was negatively correlated with that of MG7\u2010Ag and MMP9. Of all AG, those with low expression of PGC and high expression of MG7\u2010Ag and MMP9 may possess a greater potential of malignant transformation. Combined detection of negative marker PGC and positive markers MG7\u2010Ag and MMP9 could be used as a potential follow\u2010up panel for monitoring dynamical progression of AG and improving the detection efficiency of high\u2010risk individuals of gastric cancer, and then taking necessary interventions on the target population.<\/jats:p>","DOI":"10.1002\/cam4.1615","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T11:51:01Z","timestamp":1530532261000},"page":"4068-4076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Correlation between negative expression of pepsinogen C and a series of phenotypic markers of gastric cancer in different gastric diseases"],"prefix":"10.1002","volume":"7","author":[{"given":"Jingyi","family":"Jiang","sequence":"first","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery Liaoning Provincial Education Department The First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University)  Shenyang China"},{"name":"Department of Biochemistry &amp; Molecular Biology China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shixuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery Liaoning Provincial Education Department The First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University)  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nannan","family":"Dong","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery Liaoning Provincial Education Department The First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University)  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery Liaoning Provincial Education Department The First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University)  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery Liaoning Provincial Education Department The First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University)  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Sun","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery Liaoning Provincial Education Department The First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University)  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7394-9036","authenticated-orcid":false,"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery Liaoning Provincial Education Department The First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University)  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i3.354"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_6_4_1","unstructured":"World Health Organisation.GLOBOCAN 2012: estimated cancer incidence mortality and prevalence. 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