{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T10:49:22Z","timestamp":1753181362857,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,15]],"date-time":"2018-07-15T00:00:00Z","timestamp":1531612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>) is the most frequent indolent lymphoma in Western countries, but it is less frequent in Asia. Several trials have demonstrated the progression\u2010free benefit of rituximab maintenance for <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> patients in Western countries. However, the overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) benefits and effectiveness of rituximab maintenance in Asian <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> patients remain uncertain. We utilized the Taiwan Cancer Registry Database and the National Health Insurance Research Database to investigate the roles of rituximab maintenance for newly diagnosed <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> patients in Taiwan. Among 836 patients with newly diagnosed <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> during 2009\u20102012, we enrolled patients with stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> diseases receiving 4\u20108 cycles of rituximab\u2010containing induction chemotherapies (R\u2010induction). We excluded those who died or received additional chemotherapy within 180\u00a0days after R\u2010induction. Among the 396 enrolled patients, 260 underwent rituximab maintenance (R\u2010maintenance group), and 136 served as the observation group. The R\u2010maintenance group received less anthracycline and fewer cycles of R\u2010induction than the observation group, but they exhibited a significantly better <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> both in the univariate and multivariate analyses [hazard ratio, 0.42; 95% confidence interval, 0.19\u20100.91] after adjusting for age, sex, and Ann Arbor stages. Meanwhile, we also found more patients required further therapies in the first 6\u00a0months after the cease of rituximab maintenance. In the subgroup analysis, patients older than 60\u00a0years or with stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> diseases benefited more from rituximab maintenance. Conclusively, our nationwide study is the first one to demonstrate the <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> benefit of rituximab maintenance after induction therapies in newly diagnosed <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> patients from Asian populations.<\/jats:p>","DOI":"10.1002\/cam4.1622","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T03:05:26Z","timestamp":1531710326000},"page":"3582-3591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Rituximab maintenance improves overall survival in follicular lymphoma: A retrospective nationwide real\u2010world analysis from Taiwan Cancer Registry Database"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3098-6371","authenticated-orcid":false,"given":"Huai\u2010Hsuan","family":"Huang","sequence":"first","affiliation":[{"name":"Division 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