{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:20:19Z","timestamp":1791534019182,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,14]],"date-time":"2018-07-14T00:00:00Z","timestamp":1531526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The role of induction chemotherapy in nasopharyngeal carcinoma (<jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content>) remains controversial. The primary aim of this study was to use the National Cancer Database to evaluate the patterns of care of induction chemotherapy in <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> and its impact on overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>). Patients with <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> from 2004 to 2014 were obtained from the <jats:styled-content style=\"fixed-case\">NCDB<\/jats:styled-content>. Patients were considered to have received induction chemotherapy if it was started \u226543\u00a0days before the start of <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> and concurrent <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> if chemotherapy started within 21\u00a0days after the start of <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>. Propensity score matching was used to control for selection bias. Cox proportional hazards model was used to determine significant predictors of <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>. Logistic regression model was used to determine predictors of the use of induction chemotherapy. Significance was defined as a <jats:italic>P<\/jats:italic> value &lt;.05. A total of 4857 patients were identified: 4041 patients (87.2%) received concurrent <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> and 816 patients (16.8%) received induction chemotherapy. The use of induction therapy remained stable between 2004 and 2014. Younger patients and those with higher T\u2010 and N\u2010stage had a higher likelihood of being treated with induction chemotherapy. The 5\u2010year <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> in patients treated with induction chemotherapy and <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> was 66.3% vs 69.1%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.25). There was no difference in <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> when these two groups were analyzed after propensity score matching. No differences in <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> existed between these treatment groups in patients with T3\u2010T4N1 or TanyN2\u20103 disease (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.76). Propensity score matching also did not reveal any difference in <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> in patients with T3\u2010T4N1 or TanyN2\u20103 disease. The use of induction chemotherapy has remained stable in the last decade. In this study of patients with <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content>, induction chemotherapy was not associated with improved <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> alone.<\/jats:p>","DOI":"10.1002\/cam4.1626","type":"journal-article","created":{"date-parts":[[2018,7,15]],"date-time":"2018-07-15T04:11:46Z","timestamp":1531627906000},"page":"3592-3603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Induction chemotherapy in the treatment of nasopharyngeal carcinoma: Clinical outcomes and patterns of care"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5832-8194","authenticated-orcid":false,"given":"Prashant","family":"Gabani","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Washington University School of 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Adkins","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Washington University School of Medicine  Saint Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason T.","family":"Rich","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Washington University School of Medicine  Saint Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose P.","family":"Zevallos","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Washington University School of Medicine  Saint Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mackenzie D.","family":"Daly","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Washington University School of Medicine  Saint Louis MO 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