{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:25:28Z","timestamp":1781083528412,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T00:00:00Z","timestamp":1530576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010425","name":"TSGH","doi-asserted-by":"crossref","award":["C107-069"],"award-info":[{"award-number":["C107-069"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Radiotherapy (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>) is an effective treatment for breast cancer. The side effects of breast irradiation, including skin toxicity in the irradiation field, cause considerable discomfort. This study compared the severity of skin toxicity caused by image\u2010guided <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">IGRT<\/jats:styled-content>) and intensity\u2010modulated <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content>) combined with an electronic portal imaging device (<jats:styled-content style=\"fixed-case\">EPID<\/jats:styled-content>) in breast cancer. This study retrospectively analyzed 458 patients with breast cancer who had received <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>. The patients were divided into two groups: 302 and 156 patients in the <jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IGRT<\/jats:styled-content> groups. In the <jats:styled-content style=\"fixed-case\">IGRT<\/jats:styled-content> group, 8 and 148 patients had received helical tomotherapy irradiation and <jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content> with cone\u2010beam computed tomography. Simple and multiple logistic regression analyses were used to estimate the relationship between <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> technique and the severity of radiation skin toxicity. In our study, 284, 97, and 6 patients exhibited grades I, <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> radiation dermatitis (<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>). Moreover, 75 patients in the <jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content> group (24.80%) and 22 patients in the <jats:styled-content style=\"fixed-case\">IGRT<\/jats:styled-content> group (14.10%) exhibited grade <jats:styled-content style=\"fixed-case\">II RD<\/jats:styled-content>. All patients with grade <jats:styled-content style=\"fixed-case\">III RD<\/jats:styled-content> were in the <jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content> group (2.00%). No patient exhibited grade <jats:styled-content style=\"fixed-case\">IV RD<\/jats:styled-content>. The patients in the <jats:styled-content style=\"fixed-case\">IGRT<\/jats:styled-content> group exhibited less severity of <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> than in the <jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content> group. The severity of acute <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> due to <jats:styled-content style=\"fixed-case\">IGRT<\/jats:styled-content> is significantly lower than that due to <jats:styled-content style=\"fixed-case\">IMRT<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">EPID<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/cam4.1630","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T11:53:54Z","timestamp":1530618834000},"page":"3622-3629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Compared with intensity\u2010modulated radiotherapy, image\u2010guided radiotherapy reduces severity of acute radiation\u2010induced skin toxicity during radiotherapy in patients with breast cancer"],"prefix":"10.1002","volume":"7","author":[{"given":"Jang\u2010Chun","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Shuang Ho Hospital Taipei Medical University  Taipei Taiwan"},{"name":"Department of Radiology School of Medicine College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u2010Ting","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Shuang Ho Hospital Taipei Medical University  Taipei Taiwan"},{"name":"Department of Radiology School of Medicine College of Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ching","family":"Chou","sequence":"additional","affiliation":[{"name":"School of Public Health National Defense Medical Center  Taipei 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