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This study aims to evaluate treatment outcomes among children, adolescents and young adults with osteosarcoma over the three decades by the changes in the long\u2010term relative survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Osteosarcoma incidence and relative survival data from Surveillance, Epidemiology, and End Results (SEER) registries during 1984\u20102013 were analyzed. The survival differences over three decades, age, sex, race, and socioeconomic status (SES) were assessed by comparing Kaplan\u2010Meier curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall incidence of osteosarcoma kept relatively stable with 0.4 per 100\u00a0000 in the three decades with the peak incidence occurring in the aged 10\u201019 group. The 10\u2010year relative survival rate (RSR) increased from 57.7% to 61.0% in the three decades, with the greatest increase in the aged 0\u20109 group from 48.2% to 65.7%. The 10\u2010year RSR improved from 54.1% to 61.5% in males, and from 62.4% to 63.0% in females, respectively, in the three decades. Furthermore, survival dramatically improved from 30% to 60% in the high\u2010poverty group over the three decades.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated that the overall incidence of osteosarcoma remained stable, with an improvement in survival in the three decades. The improved survival was greater in males than in females in the three decades. Furthermore, the survival significantly increased in high\u2010poverty group, which was attributed to increasing improved health care system and patients with low finance can also have access to receiving effective and consistent treatment without distinction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.1659","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T03:31:50Z","timestamp":1531279910000},"page":"3652-3661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Increased survival of patients aged 0\u201029\u00a0years with osteosarcoma: A period analysis, 1984\u20102013"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6489-0573","authenticated-orcid":false,"given":"Jinna","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Oncology The Fifth Affiliated Hospital of Sun Yat\u2010sen University  Zhuhai Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Oncology The Fifth Affiliated Hospital of Sun Yat\u2010sen University  Zhuhai Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqing","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery The Fifth Affiliated Hospital of Sun Yat\u2010sen University  Zhuhai Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuibo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery The Fifth Affiliated Hospital of Sun Yat\u2010sen University  Zhuhai Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuandong","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changye","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Oncology The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Oncology The Fifth Affiliated Hospital of Sun Yat\u2010sen University  Zhuhai Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950101)75:1 <203::AID-CNCR2820751308>3.0.CO;2-V"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.96B10.34370"},{"key":"e_1_2_7_4_1","volume-title":"Pathology and genetics of soft tissue and bone","author":"Fletcher C","year":"2002"},{"key":"e_1_2_7_5_1","unstructured":"What are the key statistics about osteosarcoma\u2013Atlanta: American Cancer Society 2015.http:\/\/www.cancer.org\/cancer\/osteosarcoma\/detailedguide\/osteosarcoma-key-statistics. 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