{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:29:21Z","timestamp":1780471761908,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,8,18]],"date-time":"2018-08-18T00:00:00Z","timestamp":1534550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["17ZR1403500"],"award-info":[{"award-number":["17ZR1403500"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To compare the survival impact of several lymph node staging methods and therapeutic role of lymphadenectomy in patients with epithelial ovarian cancer who had undergone lymphadenectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were retrospectively collected from the Surveillance, Epidemiology, and End Results program between 1988 and 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An increasing number of resected lymph nodes (<jats:styled-content style=\"fixed-case\">RLN<\/jats:styled-content>s) was associated with a significant improvement in survival of FIGO stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> disease. However, for FIGO stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> patients, better survival was not significantly associated with a more extensive lymphadenectomy. A higher lymph node ratio (<jats:styled-content style=\"fixed-case\">LNR<\/jats:styled-content>) and log odds of positive lymph nodes (<jats:styled-content style=\"fixed-case\">LODDS<\/jats:styled-content>) were associated with poorer survival regardless of stage. Nevertheless, four\u2010category classification of <jats:styled-content style=\"fixed-case\">LODDS<\/jats:styled-content> was more suitable for stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> patients when three\u2010category classification was compatible with stage I\u2010<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> disease. Multivariate analysis demonstrated that <jats:styled-content style=\"fixed-case\">LODDS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LNR<\/jats:styled-content> were significant independent prognostic factors, but not <jats:styled-content style=\"fixed-case\">RLN<\/jats:styled-content> classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sixteen to thirty <jats:styled-content style=\"fixed-case\">RLN<\/jats:styled-content>s are recommended for stage I disease. For stages <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> patients, the more lymph node excision, the better the prognosis. However, lymphadenectomy was nonessential for stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> patients. Considering staging methods, for stages <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> patients, three\u2010category classification of <jats:styled-content style=\"fixed-case\">LODDS<\/jats:styled-content> was recommended to evaluate the prognosis. For stage I and <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>, three\u2010category classification of positive <jats:styled-content style=\"fixed-case\">LNR<\/jats:styled-content> was idoneous.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.1680","type":"journal-article","created":{"date-parts":[[2018,8,19]],"date-time":"2018-08-19T04:10:02Z","timestamp":1534651802000},"page":"4315-4329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Survival effect of different lymph node staging methods on ovarian cancer: An analysis of 10 878 patients"],"prefix":"10.1002","volume":"7","author":[{"given":"Jieyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gynecology Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecology Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gynecology Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1639-9549","authenticated-orcid":false,"given":"Xin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gynecology Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,18]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"853","volume-title":"Epithelial ovarian cancer. 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