{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:12:48Z","timestamp":1790921568005,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T00:00:00Z","timestamp":1387238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orway, Pap smears with atypical squamous cells of uncertain significance (<jats:styled-content style=\"fixed-case\">ASCUS<\/jats:styled-content>) and low\u2010grade squamous intraepithelial lesions (<jats:styled-content style=\"fixed-case\">LSIL<\/jats:styled-content>) are triaged after 6\u00a0months. The aim of the study was to evaluate effects of implementing human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) test (2005) in delayed triage of<jats:styled-content style=\"fixed-case\">ASCUS<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">LSIL<\/jats:styled-content>in a cohort of women from<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>estern<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orway. After a survey of 119,469 cervical Pap smears during 2005\u20132007, a total of 1055 women with an index<jats:styled-content style=\"fixed-case\">ASCUS<\/jats:styled-content>or<jats:styled-content style=\"fixed-case\">LSIL<\/jats:styled-content>were included in the study and followed up for 3\u20136\u00a0years with respect to progression into cervical intraepithelial neoplasia grade 2 or worse (<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+). Overall sensitivity for detection of<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ with<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>testing and cytology was 96% and 72%, respectively. The sensitivity for detection of<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ was not affected by age, but the specificity of the<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>test increased with age. Thus, for the age groups &lt;34\u00a0years, 34\u201350\u00a0years, and &gt;50\u00a0years, the specificity of a positive<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>test to detect<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ was 47%, 71%, and 82%, respectively. Positive predictive values for<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ in women with positive cytology, positive<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>test, negative cytology, negative<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>test, or negative<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>and cytology tests were 52%, 41%, 8%, 1.5%, and 0.4%, respectively.<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>testing resulted in a net 22% increased detection of<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+. Fifty\u2010six percent of<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ was detected at an earlier time point with<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>testing in triage. Implementation of<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>testing in delayed triage of<jats:styled-content style=\"fixed-case\">ASCUS<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">LSIL<\/jats:styled-content>improved the stratification of<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ risk and increased<jats:styled-content style=\"fixed-case\">CIN<\/jats:styled-content>2+ detection and at an earlier time point than with triage by cytology alone.<\/jats:p>","DOI":"10.1002\/cam4.171","type":"journal-article","created":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T11:06:44Z","timestamp":1387278404000},"page":"182-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<scp>HPV DNA<\/scp>testing improves<scp>CIN<\/scp>2+ risk stratification and detection of<scp>CIN<\/scp>2+ in delayed triage of<scp>ASCUS<\/scp>and<scp>LSIL<\/scp>. A population\u2010based follow\u2010up study from<scp>W<\/scp>estern<scp>N<\/scp>orway"],"prefix":"10.1002","volume":"3","author":[{"given":"Elisabeth B.","family":"Budal","sequence":"first","affiliation":[{"name":"Department of Pathology Haukeland University Hospital N\u20102021 Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans K.","family":"Haugland","sequence":"additional","affiliation":[{"name":"Department of Pathology Haukeland University Hospital N\u20102021 Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Skar","sequence":"additional","affiliation":[{"name":"Department of Pathology Haukeland University Hospital N\u20102021 Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn O.","family":"M\u00e6hle","sequence":"additional","affiliation":[{"name":"Department of Pathology Haukeland University Hospital N\u20102021 Bergen Norway"},{"name":"Section for Pathology Department of Clinical Medicine University of Bergen N\u20105021 Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tone","family":"Bj\u00f8rge","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen Bergen Norway"},{"name":"Norwegian Institute of Public Health Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav K.","family":"Vintermyr","sequence":"additional","affiliation":[{"name":"Department of Pathology Haukeland University Hospital N\u20102021 Bergen Norway"},{"name":"Section for Pathology Department of Clinical Medicine University of Bergen N\u20105021 Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5826"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199304000-00018"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04956-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/314111a0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.9.690"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61416-0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70103-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1989.236"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00063-W"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7193.1244"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1002\/ijc.23276","article-title":"Mass screening programmes and trends in cervical cancer in Finland and the Netherlands","volume":"122","author":"Aa M. 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