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MPNST<\/jats:styled-content>s can occur either sporadically or in association with the neurofibromatosis type 1 (NF<\/jats:styled-content>1) syndrome. Importantly, activation of RAS<\/jats:styled-content>\/RAF<\/jats:styled-content>\/MEK<\/jats:styled-content>\/ERK<\/jats:styled-content>, PI<\/jats:styled-content>3K\/AKT<\/jats:styled-content>\/mTOR<\/jats:styled-content>, and WNT<\/jats:styled-content>\/CTNNB<\/jats:styled-content>1 signaling pathways has been reported in both NF<\/jats:styled-content>1\u2010related and late\u2010stage sporadic MPNST<\/jats:styled-content>s. In this study, we found that DAW<\/jats:styled-content>22, a natural sesquiterpene coumarin compound isolated from Ferula ferulaeoides (Steud.) Korov<\/jats:italic>., could inhibit cell proliferation and colony formation in five established human MPNST<\/jats:styled-content> cancer cell lines. Further molecular mechanism exploration indicated that DAW<\/jats:styled-content>22 could target the main components in the MPNST<\/jats:styled-content> tumorigenic pathways: namely suppress phosphorylation of AKT<\/jats:styled-content> and ERK<\/jats:styled-content>, and reduce levels of non\u2010phospho (active) CTNNB<\/jats:styled-content>1. Using the xenograft mouse model transplanted with human MPNST<\/jats:styled-content> cancer cell line, daily treatment with DAW<\/jats:styled-content>22 for 25\u00a0days was effective in reducing tumor growth. These results support DAW<\/jats:styled-content>22 as an alternative therapeutic compound for MPNST<\/jats:styled-content> treatment by affecting multiple signaling transduction pathways in its disease progression.<\/jats:p>","DOI":"10.1002\/cam4.1732","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T04:13:45Z","timestamp":1534392825000},"page":"4791-4800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Targeting of AKT<\/scp>\/ERK<\/scp>\/CTNNB<\/scp>1 by DAW<\/scp>22 as a potential therapeutic compound for malignant peripheral nerve sheath tumor"],"prefix":"10.1002","volume":"7","author":[{"given":"Xiao\u2010Xiao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Kowloon Hong 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