{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:01:19Z","timestamp":1790438479454,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T00:00:00Z","timestamp":1534377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although the prognosis of core\u2010binding factor (<jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>) acute myeloid leukemia (<jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>) is better than other subtypes of <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>, 30% of patients still relapse and may require allogeneic hematopoietic cell transplantation (allo<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>). However, there is no validated widely accepted scoring system to predict patient subsets with higher risk of relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eleven centers in the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> and Europe evaluated 247 patients with t(8;21)(q22;q22).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete remission (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) rate was high (92.7%), yet relapse occurred in 27.1% of patients. A total of 24.7% of patients received allo<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>. The median disease\u2010free (<jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content>) and overall (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) survival were 20.8 and 31.2\u00a0months, respectively. Age, <jats:italic><jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content><\/jats:italic> D816V mutated (11.3%) or nontested (36.4%) compared with <jats:italic><jats:styled-content style=\"fixed-case\">KIT<\/jats:styled-content><\/jats:italic> D816V wild type (52.5%), high white blood cell counts (<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>), and pseudodiploidy compared with hyper\u2010 or hypodiploidy were included in a scoring system (named I\u2010<jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>it). <jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content> rate at 2\u00a0years was 76% for patients with a low\u2010risk I\u2010<jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>it score compared with 36% for those with a high\u2010risk I\u2010<jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>it score (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001). Low\u2010 vs high\u2010risk <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> at 2\u00a0years was 89% vs 51% (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>I\u2010<jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>it composed of readily available risk factors can be useful to tailor the therapy of patients, especially for whom allo<jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content> is not need in <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>1 (ie, patients with a low\u2010risk I\u2010<jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>it score).<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.1733","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T02:36:27Z","timestamp":1534473387000},"page":"4447-4455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Core\u2010binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I\u2010<scp>CBF<\/scp>it)"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6896-6213","authenticated-orcid":false,"given":"Celalettin","family":"Ustun","sequence":"first","affiliation":[{"name":"Division of Hematology, Oncology and Transplantation Department of Medicine University of Minnesota  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Pathology Harvard Medical School Brigham and Women's Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica E. 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