{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:42:14Z","timestamp":1781739734863,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T00:00:00Z","timestamp":1534204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are controversial data supporting the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with advanced lung squamous cell carcinoma (SCC). In this study, the efficacy of icotinib in unselected and <jats:italic>EGFR<\/jats:italic>\u2010mutated patients with lung SCC was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the survival time of unselected advanced lung SCC patients treated with icotinib for at least 5\u00a0months between June 2013 and June 2016, and selected appropriate <jats:italic>EGFR\u2010<\/jats:italic>mutated advanced lung ADC patients to have 1:1 ratio of propensity score matching with <jats:italic>EGFR<\/jats:italic>\u2010mutated advanced lung SCC patients, and matching factors were age, sex, clinical stage, Karnofsky performance status (KPS), smoking history, <jats:italic>EGFR<\/jats:italic> mutation type, and treatment lines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 487 unselected advanced lung SCC patients were available for analysis of icotinib treatment efficacy. The progression\u2010free survival (PFS) was 13.0\u00a0months (95% CI 12.2\u201013.8), the overall survival (OS) was 16.0\u00a0months (95% CI 14.7\u201017.3), and the objective response rate (ORR) was 41.3%. After propensity score matching, 78 <jats:italic>EGFR<\/jats:italic>\u2010mutated lung SCC and 78 <jats:italic>EGFR<\/jats:italic>\u2010mutated lung ADC patients were selected and compared. Although no statistical difference was found, ADC patients were associated with a longer PFS (15.8\u00a0months vs 12.7\u00a0months, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.275) and OS (24.2\u00a0months vs 18.5\u00a0months, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.150), and a better ORR (59.0% vs 48.7%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.199) than compared with SCC patients when treated with icotinib.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Icotinib has a modest therapeutic effect in patients with advanced lung SCC, especially for the population with <jats:italic>EGFR<\/jats:italic> mutations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.1736","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T05:13:28Z","timestamp":1534310008000},"page":"4456-4466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy of icotinib in advanced lung squamous cell carcinoma"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4133-3429","authenticated-orcid":false,"given":"Shuai","family":"Liang","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical 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