{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:55:24Z","timestamp":1792698924508,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T00:00:00Z","timestamp":1535414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T00:00:00Z","timestamp":1535414400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772987"],"award-info":[{"award-number":["81772987"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Abstract<\/jats:title>\n \n Multidimensional interactions of multiple factors are more important in promoting cancer initiation. Gene\u2010gene interactions between protein\u2010coding genes have been paid great attention, while rare studies refer to the interactions between encoding and noncoding genes. Our research group previously found encoding gene\n PGC<\/jats:styled-content>\n polymorphisms could affect the susceptibility to atrophic gastritis (\n AG<\/jats:styled-content>\n ) and gastric cancer (\n GC<\/jats:styled-content>\n ). Interestingly, several\n SNP<\/jats:styled-content>\n s in long noncoding\n RNA<\/jats:styled-content>\n (lnc\n RNA<\/jats:styled-content>\n ) genes, just adjacent to\n PGC<\/jats:styled-content>\n , were found to be associated with\n AG<\/jats:styled-content>\n risk and\n GC<\/jats:styled-content>\n prognosis afterward. This study aims to explore the\n SNP<\/jats:styled-content>\n interactions between\n PGC<\/jats:styled-content>\n and its neighbor lnc\n RNA<\/jats:styled-content>\n s on the risk of\n AG<\/jats:styled-content>\n and\n GC<\/jats:styled-content>\n . Genotyping for seven\n PGC SNP<\/jats:styled-content>\n s and seven lnc\n RNA SNP<\/jats:styled-content>\n s was conducted using Sequenom Mass\n ARRAY<\/jats:styled-content>\n platform in a total of 2228 northern Chinese subjects, including 536\n GC<\/jats:styled-content>\n cases, 810\n AG<\/jats:styled-content>\n cases, and 882 controls. We found 15 pairwise\n PGC<\/jats:styled-content>\n \u2010lnc\n RNA<\/jats:styled-content>\n s\n SNP<\/jats:styled-content>\n s had interactions: Five pairs were associated with\n AG<\/jats:styled-content>\n risk, and ten pairs were associated with\n GC<\/jats:styled-content>\n risk. Moreover, two\n GC<\/jats:styled-content>\n \u2010related interactions\n PGC<\/jats:styled-content>\n rs6939861 with lnc\u2010C6orf\u2010132\u20101 rs7749023 and rs7747696 survived the Bonferroni correction (\n P<\/jats:italic>\n correction<\/jats:sub>\n \u00a0=\u00a00.049 and 0.007, respectively). Several combinations showed obvious epistasis and cumulative effects on disease risk. Some three\u2010way interactions of\n SNP<\/jats:styled-content>\n s with smoking and drinking could also be observed. Besides, a few interacting\n SNP<\/jats:styled-content>\n s showed correlations with the expression levels of\n PGC<\/jats:styled-content>\n protein and related lnc\n RNA<\/jats:styled-content>\n s in serum. Our study would provide research clues for further screening combination biomarkers uniting both protein\u2010coding and noncoding genes with the potential in prediction of the susceptibility to\n GC<\/jats:styled-content>\n and its precursor.\n <\/jats:p>","DOI":"10.1002\/cam4.1743","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T01:45:00Z","timestamp":1535593500000},"page":"5252-5271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["SNP<\/scp>\n interactions of\n PGC<\/scp>\n with its neighbor lnc\n RNA<\/scp>\n s enhance the susceptibility to gastric cancer\/atrophic gastritis and influence the expression of involved molecules"],"prefix":"10.1002","volume":"7","author":[{"given":"Zhi","family":"Lv","sequence":"first","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery China Medical University First Hospital Shenyang China"},{"name":"The Key Laboratory of Cancer Etiology and Prevention Liaoning Provincial Education Department China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Sun","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery China Medical University First Hospital Shenyang China"},{"name":"The Key Laboratory of Cancer Etiology and Prevention Liaoning Provincial Education Department China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery China Medical University First Hospital Shenyang China"},{"name":"The Key Laboratory of Cancer Etiology and Prevention Liaoning Provincial Education Department China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Gong","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery China Medical University First Hospital Shenyang China"},{"name":"The Key Laboratory of Cancer Etiology and Prevention Liaoning Provincial Education Department China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Jing","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery China Medical University First Hospital Shenyang China"},{"name":"The Key Laboratory of Cancer Etiology and Prevention Liaoning Provincial Education Department China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Dong","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery China Medical University First Hospital Shenyang China"},{"name":"The Key Laboratory of Cancer Etiology and Prevention Liaoning Provincial Education Department China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6463-019X","authenticated-orcid":false,"given":"Chengzhong","family":"Xing","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery China Medical University First Hospital Shenyang China"},{"name":"The Key Laboratory of Cancer Etiology and Prevention Liaoning Provincial Education Department China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7394-9036","authenticated-orcid":false,"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Tumor Etiology and Screening Department of Cancer Institute and General Surgery China Medical University First Hospital Shenyang China"},{"name":"The Key Laboratory of Cancer Etiology and Prevention Liaoning Provincial Education Department China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303434"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv036"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevOncog.2013007254"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.9.1.1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033531"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2016.10.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2428"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/481607"},{"key":"e_1_2_6_10_1","first-page":"177","article-title":"Epithelial cell differentiation during stomach development","volume":"13","author":"Yasugi S","year":"2000","journal-title":"Hum Cell"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i17.2545"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115955"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgt079"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20115"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29005"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2001\/367832"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25537"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22305"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059688"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.3670"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089160909500103"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9132-y"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047178"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-1683-z"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.4077\/CJP.2009.AMH076"},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"20235","DOI":"10.18632\/oncotarget.15664","article-title":"Polymorphisms in human telomerase reverse transcriptase (hTERT) gene, gene\u2010 gene and gene\u2010smoking interaction with susceptibility to gastric cancer in Chinese Han population","volume":"8","author":"Zhang J","year":"2017","journal-title":"Oncotarget"},{"key":"e_1_2_6_28_1","first-page":"967","article-title":"Effects of interleukin\u201010 polymorphisms and smoking on the risk of gastric cancer in Taiwan","volume":"28","author":"Kuo WH","year":"2014","journal-title":"In Vivo"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-238"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3703-9"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-014-0127-3"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr067"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840060330"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00040.2012"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agh105"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39528"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06692.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28470"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20149"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.1743","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.1743","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.1743","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.1743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T12:01:46Z","timestamp":1781092906000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.1743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,28]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/cam4.1743"],"URL":"https:\/\/doi.org\/10.1002\/cam4.1743","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,28]]},"assertion":[{"value":"2018-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}