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Here, coculture experiments showed that TGF\u2010\u03b2 pretreatment increased the migration and invasion potential of lung cancer cells and TGF\u2010\u03b2 pretreated A549 cells increases vascular permeability. Furthermore, we found that TGF\u2010\u03b2\u2010mediated exosomes, as carriers of intercellular communication, regulated lung cancer invasion, and vascular permeability. Transcriptional analysis also revealed that lnc\u2010MMP2\u20102 was highly enriched in TGF\u2010\u03b2\u2010mediated exosomes and might function by increasing the expression of matrix metalloproteinase (MMP)2 through its enhancer activity, with ectopic expression and silencing of lnc\u2010MMP2\u20102 affecting lung cancer invasion and vascular permeability. Additionally, lnc\u2010MMP2\u20102 and MMP2 expression was assessed semiquantitatively, and tissue\u2010specific correlations between lnc\u2010MMP2\u20102 and MMP2 expression were evaluated. These results suggested that exosomal lnc\u2010MMP2\u20102 might regulate the migration and invasion of lung cancer cells into the vasculature by promoting MMP2 expression, suggesting this lncRNA as a novel therapeutic target and predictive marker of tumor metastasis in lung cancer.<\/jats:p>","DOI":"10.1002\/cam4.1758","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T05:42:08Z","timestamp":1536212528000},"page":"5118-5129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["TGF\u2010\u03b2\u2010mediated exosomal lnc\u2010MMP2\u20102 regulates migration and invasion of lung cancer cells to the vasculature by promoting MMP2 expression"],"prefix":"10.1002","volume":"7","author":[{"given":"Dong\u2010ming","family":"Wu","sequence":"first","affiliation":[{"name":"Clinical Laboratory The First Affiliated Hospital of Chengdu Medical College  Chengdu 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