{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:20:20Z","timestamp":1790666420130,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Significant increases in childhood cancer incidence since the 1970s have been consistently reported worldwide, but the persistence of the increase on recent periods is discussed. No conclusion can be drawn concerning the spatial variations of childhood cancer, either. This study is an in\u2010depth investigation of the spatial and temporal variations of childhood cancer in France. An extensive review of all the studies published since 2000 on those issues is provided.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 25\u00a0877 cases of childhood cancer registered nationwide over 2000\u20102014. The spatial heterogeneity (overdispersion, autocorrelation, overall heterogeneity) was tested, on two geographic scales, and two spatial scan methods were used to detect clusters of cases. The annual average percent change (AAPC) in incidence rate was estimated with Poisson regression models, and joinpoint analyses were considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Glioma and non\u2010Hodgkin lymphoma cases exhibited some spatial heterogeneity and two large clusters were detected. Overall, the incidence rate of childhood cancer was stable over 2000\u20102014 (AAPC\u00a0=\u00a0\u22120.1% [\u22120.3%; 0.2%]). A log\u2010linear positive trend was significantly evidenced for gliomas other than pilocytic astrocytomas (AAPC\u00a0=\u00a01.8% [0.9%; 2.7%]), with some suggestion of a leveling\u2010off at the end of the period, while Burkitt lymphoma and germ cell tumor incidence rates decreased (AAPC\u00a0=\u00a0\u22122.2% [\u22123.8%; \u22120.5%] and AAPC\u00a0=\u00a0\u22121.9% [\u22123.4%; \u22120.3%], respectively). No spatial heterogeneity or significant time variation was evidenced for other cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Several types of childhood cancer displayed some spatial heterogeneity and two large clusters were detected, the origins of which are to be investigated and might include differences in case ascertainment. Overall, the results do not support a sustained increase in incidence rates of childhood cancer in recent years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.1774","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T09:27:32Z","timestamp":1537349252000},"page":"5299-5314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Spatial and temporal variations of childhood cancers: Literature review and contribution of the French national registry"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4149-2246","authenticated-orcid":false,"given":"St\u00e9phanie","family":"Goujon","sequence":"first","affiliation":[{"name":"Epid\u00e9miologie des Cancers de l'enfant et de l'adolescent Team (EPICEA) UMR 1153 Epidemiology and Biostatistics Sorbonne Paris Cit\u00e9 Research Center (CRESS) Inserm  Villejuif France"},{"name":"Sorbonne Paris Cit\u00e9 Paris Descartes University  Paris France"},{"name":"French National Registry of Childhood Hematological Malignancies (RNHE)  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Kyrimi","sequence":"additional","affiliation":[{"name":"Epid\u00e9miologie des Cancers de l'enfant et de l'adolescent Team (EPICEA) UMR 1153 Epidemiology and Biostatistics Sorbonne Paris Cit\u00e9 Research Center (CRESS) Inserm  Villejuif France"},{"name":"Sorbonne Paris Cit\u00e9 Paris Descartes University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Faure","sequence":"additional","affiliation":[{"name":"Epid\u00e9miologie des Cancers de l'enfant et de l'adolescent Team (EPICEA) UMR 1153 Epidemiology and Biostatistics Sorbonne Paris Cit\u00e9 Research Center (CRESS) Inserm  Villejuif France"},{"name":"Sorbonne Paris Cit\u00e9 Paris Descartes University  Paris France"},{"name":"French National Registry of Childhood Hematological Malignancies (RNHE)  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Guissou","sequence":"additional","affiliation":[{"name":"Epid\u00e9miologie des Cancers de l'enfant et de l'adolescent Team (EPICEA) UMR 1153 Epidemiology and Biostatistics Sorbonne Paris Cit\u00e9 Research Center (CRESS) Inserm  Villejuif France"},{"name":"Sorbonne Paris Cit\u00e9 Paris Descartes University  Paris France"},{"name":"French National Registry of Childhood Solid Tumors (RNTSE) Facult\u00e9 de M\u00e9decine CHU Nancy  Vandoeuvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"H\u00e9mon","sequence":"additional","affiliation":[{"name":"Epid\u00e9miologie des Cancers de l'enfant et de l'adolescent Team (EPICEA) UMR 1153 Epidemiology and Biostatistics Sorbonne Paris Cit\u00e9 Research Center (CRESS) Inserm  Villejuif France"},{"name":"Sorbonne Paris Cit\u00e9 Paris Descartes University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Lacour","sequence":"additional","affiliation":[{"name":"Epid\u00e9miologie des Cancers de l'enfant et de l'adolescent Team (EPICEA) UMR 1153 Epidemiology and Biostatistics Sorbonne Paris Cit\u00e9 Research Center (CRESS) Inserm  Villejuif France"},{"name":"Sorbonne Paris Cit\u00e9 Paris Descartes University  Paris France"},{"name":"French National Registry of Childhood Solid Tumors (RNTSE) Facult\u00e9 de M\u00e9decine CHU Nancy  Vandoeuvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3616-7676","authenticated-orcid":false,"given":"Jacqueline","family":"Clavel","sequence":"additional","affiliation":[{"name":"Epid\u00e9miologie des Cancers de l'enfant et de l'adolescent Team (EPICEA) UMR 1153 Epidemiology and Biostatistics Sorbonne Paris Cit\u00e9 Research Center (CRESS) Inserm  Villejuif France"},{"name":"Sorbonne Paris Cit\u00e9 Paris Descartes University  Paris France"},{"name":"French National Registry of Childhood Hematological Malignancies (RNHE)  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e32833876c0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05166.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20910"},{"key":"e_1_2_8_6_1","first-page":"475","volume-title":"Spatial Epidemiology \u2010 Methods and Applicationsed","author":"Elliott P","year":"2000"},{"key":"e_1_2_8_7_1","first-page":"17","article-title":"Notes on continuous stochastic phenomena","volume":"27","author":"Moran PAP","year":"1948","journal-title":"Biometrika"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-4632.1999.tb00973.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2490"},{"key":"e_1_2_8_10_1","unstructured":"KulldorffM Information Management Services Inc.SaTScan\u2122 v9.4.2: software for the spatial and space\u2010time scan statistics.2009."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-072X-4-11"},{"key":"e_1_2_8_12_1","unstructured":"TakahashiK YokoyamaT TangoT.FleXScan v3.1.2: software for the flexible scan statistic. National Institute of Public Health Japan 2013."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z"},{"key":"e_1_2_8_14_1","unstructured":"Joinpoint Regression Program.Version 4.3.1.0. Statistical research and applications branch. April2016. National Cancer Institute."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-013-1212-5"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annpat.2014.01.002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.07.028"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30186-9"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605503"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28903"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.296"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23169"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq092"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3926"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21219"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21567"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181805"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200404000-00002"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29015"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.24095\/hpcdp.32.3.03","article-title":"Trends in incidence of childhood cancer in Canada, 1992\u20102006","volume":"32","author":"Mitra D","year":"2012","journal-title":"Chronic Dis Inj Can"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-013-0188-y"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-015-0558-8"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-1989"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000075952"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25571"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23281"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30487"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2013.01.001"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.07.006"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23965"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602980"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9488-7"},{"key":"e_1_2_8_43_1","volume-title":"Methods for Investigating Localized Clustering of Disease","author":"Alexander FE","year":"1996"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2011.613091"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-011-9755-2"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-012-9582-0"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1078\/1438-4639-00327"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-072X-6-13"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127273"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000386"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e32834e31d8"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.08.020"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcam4.1774","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.1774","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.1774","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.1774","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T12:02:43Z","timestamp":1781092963000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.1774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,19]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/cam4.1774"],"URL":"https:\/\/doi.org\/10.1002\/cam4.1774","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,19]]},"assertion":[{"value":"2018-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}