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However, malignant lymphoma is a severe and frequent complication seen in patients with acquired immunodeficiency syndrome (<jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content>). The diagnostic criteria for some categories of <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content>\u2010related lymphoma were revised in the World Health Organization International Classification of Lymphoma, fourth edition. The purpose of this study was to assess the clinicopathological characteristics of Japanese patients with <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content>\u2010related lymphoma according to the revised classification. In this retrospective study, 207 <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content>\u2010related lymphoma cases diagnosed between 1987 and 2012 in Japan were subjected to histological subtyping and clinicopathological analyses. Diffuse large B\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>) was the predominant histological subtype throughout the study period (<jats:italic>n<\/jats:italic>\u00a0=\u00a0104, 50%). Among the <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> cases, 24% were of the germinal center (<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>) type and 76% were of the non\u2010<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> type. Non\u2010<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u2010type cases showed a significantly lower 1\u2010year survival rate (43%) than the <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u2010type cases (82%). Cases of Burkitt lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a057, 28%), plasmablastic lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a016, 8%), primary effusion lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a09, 4%), Hodgkin lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a08, 4%), and large B\u2010cell lymphoma arising in Kaposi sarcoma\u2010associated herpesvirus\u2010associated multicentric Castleman disease (<jats:italic>n<\/jats:italic>\u00a0=\u00a02, 1%) were also observed. Hodgkin lymphoma was more common in patients receiving <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content> (11.1%) than in <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>\u2010na\u00efve patients (1.4%). Statistical analyses identified CD10 negativity, BCL\u20106 negativity, Epstein\u2013Barr virus positivity, and Kaposi sarcoma\u2010associated herpesvirus positivity as risk factors for poor prognosis. This information will help in the early diagnosis of lymphoma in patients with <jats:styled-content style=\"fixed-case\">AIDS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/cam4.178","type":"journal-article","created":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T07:24:51Z","timestamp":1389338691000},"page":"143-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Classification of <scp>AIDS<\/scp>\u2010related lymphoma cases between 1987 and 2012 in Japan based on the <scp>WHO<\/scp> classification of lymphomas, fourth edition"],"prefix":"10.1002","volume":"3","author":[{"given":"Yasunori","family":"Ota","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Institute of Medical Science The University of Tokyo Shirokanedai 4\u20106\u20101 Minato\u2010ku Tokyo 108\u20108639 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzuko","family":"Moritani","sequence":"additional","affiliation":[{"name":"Department of Pathology Nagoya Medical Center 4\u20101\u20101 Sannomaru Nakaku Nagoya 460\u20100001 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Oyaizu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Institute of Medical Science The University of Tokyo Shirokanedai 4\u20106\u20101 Minato\u2010ku Tokyo 108\u20108639 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohtaro","family":"Mine","sequence":"additional","affiliation":[{"name":"Department of Pathology National Center for Global Health and Medicine Hospital 1\u201021\u20101 Toyama Shinjuku\u2010ku Tokyo 162\u20108655 Japan"},{"name":"Department of Pathology National Institute of Infectious Diseases 1\u201023\u20101 Toyama Shinjuku\u2010ku Tokyo 162\u20108640 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Ajisawa","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Tokyo Metropolitan Komagome Hospital Honkomagome 3\u201018\u201022 Bunkyo\u2010ku Tokyo 113\u20108677 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Tanuma","sequence":"additional","affiliation":[{"name":"AIDS Clinical Center National Center for Global Health and Medicine Hospital 1\u201021\u20101 Toyama Shinjuku\u2010ku Tokyo 162\u20108655 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Uehira","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Osaka National Hospital 2\u20101\u201014 Hoenzaka Chuo\u2010ku Osaka 540\u20100006 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shotaro","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Hematology National Center for Global Health and Medicine Hospital 1\u201021\u20101 Toyama Shinjuku\u2010ku Tokyo 162\u20108655 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keishiro","family":"Yajima","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Osaka National Hospital 2\u20101\u201014 Hoenzaka Chuo\u2010ku Osaka 540\u20100006 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Osaka National Hospital 2\u20101\u201014 Hoenzaka Chuo\u2010ku Osaka 540\u20100006 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Shirasaka","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Osaka National Hospital 2\u20101\u201014 Hoenzaka Chuo\u2010ku Osaka 540\u20100006 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