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In this study, we investigated the role of Cyclin G1 (CCNG1), a target gene of wild\u2010type <jats:italic>TP53<\/jats:italic> (P53wt), in HGSOC and the possible regulatory mechanism between <jats:italic>TP53<\/jats:italic> mutant (P53mt) and <jats:italic>CCNG1<\/jats:italic> in the progression of HGSOC.\u00a0High expression level of CCNG1 was found in 61.3% of HGSOC tissues and only 18.2% in fimbriae of fallopian tubes. Additionally, overexpression of CCNG1 was significantly associated with a shorter overall survival (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.0001) and progression\u2010free survival (<jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>0.0004) in HGSOC patients. In vitro, CCNG1 promoted both tumor cell motility by inducing epithelial\u2010mesenchymal transition (EMT) and resistance to cisplatin (CDDP). In vivo, knockdown expression of CCNG1 inhibited cancer metastasis. Furthermore, P53mt increased the expression of CCNG1 by regulating Notch3 expression, and a positive correlation between CCNG1 and Notch3 protein expression was observed by Immunohistochemistry (IHC) (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.39, <jats:italic>P<\/jats:italic>: 0.01528). In conclusion, the activation of P53mt\u2010Notch3\u2010CCNG1 pathway was responsible for tumor progression to advanced disease with correlation with worse prognosis in patients with HGSOC. These data suggest a possible molecular mechanism of disease and highlights CCNG1\u2019s potential role as a therapeutic target in HGSOC.<\/jats:p>","DOI":"10.1002\/cam4.1812","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T05:16:22Z","timestamp":1545196582000},"page":"351-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["CCNG1 (Cyclin G1) regulation by mutant\u2010P53 via induction of Notch3 expression promotes high\u2010grade serous ovarian cancer (HGSOC) tumorigenesis and progression"],"prefix":"10.1002","volume":"8","author":[{"given":"Ying","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Qilu Hospital Shandong University Ji'nan China"},{"name":"Gynecology Oncology Key Laboratory, Qilu Hospital Shandong University Ji'nan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Qilu Hospital Shandong University Ji'nan China"},{"name":"Gynecology Oncology Key Laboratory, Qilu Hospital Shandong University Ji'nan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Qilu Hospital Shandong University Ji'nan China"},{"name":"Gynecology Oncology Key Laboratory, Qilu Hospital Shandong University Ji'nan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samina","family":"Dongol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Qilu Hospital Shandong University Ji'nan China"},{"name":"Gynecology Oncology Key Laboratory, Qilu Hospital Shandong University Ji'nan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinuo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Qilu Hospital Shandong University Ji'nan China"},{"name":"Gynecology Oncology Key Laboratory, Qilu Hospital Shandong University Ji'nan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenjuan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Qilu Hospital Shandong University Ji'nan China"},{"name":"Gynecology Oncology Key Laboratory, Qilu Hospital Shandong University Ji'nan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifeng","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Qilu Hospital Shandong University Ji'nan China"},{"name":"Gynecology Oncology Key Laboratory, Qilu Hospital Shandong University Ji'nan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Qilu Hospital Shandong University Ji'nan China"},{"name":"Gynecology Oncology Key Laboratory, Qilu Hospital Shandong University Ji'nan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingsheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Qilu Hospital Shandong University Ji'nan China"},{"name":"Gynecology Oncology Key Laboratory, Qilu Hospital Shandong University Ji'nan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1627-1150","authenticated-orcid":false,"given":"Beihua","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Qilu Hospital Shandong University Ji'nan China"},{"name":"Gynecology Oncology Key Laboratory, Qilu Hospital Shandong University Ji'nan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2016.08.006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-014-0323-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0b013e328348a6e7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds300"},{"key":"e_1_2_7_7_1","unstructured":"OrganizationWH KurmanRJ. 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