{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:07:36Z","timestamp":1790352456948,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T00:00:00Z","timestamp":1539475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","award":["R127\u2010A8121"],"award-info":[{"award-number":["R127\u2010A8121"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Former studies on smoking as a risk factor for Philadelphia\u2010negative myeloproliferative neoplasms (MPNs) have mainly been carried out in women's cohorts and studies with various definitions of MPNs. Herein, we conducted a cohort study with register\u2010based follow\u2010up of a general population from Denmark, to validate and substantiate prior observations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the Danish Health Examination Survey cohort, we used the Cox proportional\u2010hazards model adjusted for age, sex, body mass index, and level of education, to calculate hazard ratios (HRs), to investigate, whether daily smokers or occasional\/ex\u2010smokers had an increased risk of MPNs compared to never\u2010smokers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From the time of data collection (September 2007 to October 2008) until 1 January 2015, 70 individuals were diagnosed with MPNs among 75\u00a0896 study participants. Similar results were observed in both the age and sex adjusted analysis and the multivariable analysis. The multivariable HR of any MPN diagnosis for daily smokers was 2.5 (95% CI: 1.3\u20105.0). For essential thrombocytosis, polycythemia vera, myelofibrosis, and MPN\u2010unclassified, the HRs were 1.8 (95% CI: 0.5\u20105.8), 1.7 (95% CI: 0.5\u20105.8), 4.3 (95% CI: 0.9\u201019), and 6.2 (95% CI: 1.5\u201025), respectively. Among occasional\/ex\u2010smokers the corresponding HRs were 1.9 (95% CI: 1.1\u20103.3), 1.5 (95% CI: 0.6\u20103.7), 0.8 (95% CI: 0.3\u20102.4), 0.9 (95% CI: 0.2\u20104.4), and 6.2 (95% CI: 1.8\u201021). Participants, who smoked &gt;15\u00a0g\/day, had an overall HR of 3.4 (95% CI: 1.4\u20108.2) for any MPN diagnosis, while participants who smoked \u226415\u00a0g\/day, had an overall HR of 2.1 (95% CI: 0.9\u20104.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Smoking was associated with MPN development when comparing smokers and never\u2010smokers. Further studies investigating smoking in MPNs are warranted to substantiate our findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.1815","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T03:30:31Z","timestamp":1539574231000},"page":"5796-5802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Smoking is associated with increased risk of myeloproliferative neoplasms: A general population\u2010based cohort study"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9229-4859","authenticated-orcid":false,"given":"Kasper M.","family":"Pedersen","sequence":"first","affiliation":[{"name":"Department of Hematology Zealand University Hospital, University of Copenhagen  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Bak","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital, University of Copenhagen  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders L.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital, University of Copenhagen  Roskilde Denmark"},{"name":"Institute for Inflammation Research, Centre for Rheumatology and Spine Diseases, Rigshospitalet Copenhagen University Hospital  Copenhagen  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Dorthe","family":"Zwisler","sequence":"additional","affiliation":[{"name":"REHPA, Danish Knowledge Centre for Rehabilitation and Palliative Care University of Southern Denmark and Odense University Hospital  Nyborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Ellervik","sequence":"additional","affiliation":[{"name":"Division of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Laboratory Medicine Boston Children\u2019s Hospital &amp; Harvard Medical School  Boston Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten K.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital, University of Copenhagen  Roskilde Denmark"},{"name":"Department of Science and Environment University of Roskilde  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-8032","authenticated-orcid":false,"given":"Hans C.","family":"Hasselbalch","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital, University of Copenhagen  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne S.","family":"Tolstrup","sequence":"additional","affiliation":[{"name":"National Institute of Public Health, University of Southern Denmark  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2179"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra063728"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2015.09.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2012.10.020"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-394775"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.333"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28492"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12684"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/102476"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1202626"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2339"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.125"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-534222"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.11.005"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810393557"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5462.2398"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.2011"},{"key":"e_1_2_7_21_1","volume-title":"Statistical Models in Epidemiology","author":"Clayton D","year":"1993"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21863"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010-0206"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/289645"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12256"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S99462"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.942910.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960515)77:10<2157::AID-CNCR29>3.0.CO;2-T"},{"key":"e_1_2_7_29_1","first-page":"4199","article-title":"Cigarette smoking, complete blood count, and myeloproliferative neoplasms \u2014 a meta\u2010analysis","volume":"130","author":"Jayasuriya NA","year":"2017","journal-title":"Blood"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-348144"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2013.01.004"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302X.2002.170601.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2003.09.006"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110540"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.071183"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200506000-00002"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22212"},{"key":"e_1_2_7_38_1","unstructured":"TNS Gallup and The Danish Health Authority.Monitorering af danskernes rygevaner 2008 krydstabeller alle page7.https:\/\/www.sst.dk\/da\/sundhed-og-livsstil\/tobak\/tal-og-fakta\/danskernesrygevaner\/~\/media\/6AB1E33B0868463792E86414E6DB25EF.ashx. 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